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751 articles
September 202624
Approach to personalizing the treatment of osteoporosis.
Despite the availability of multiple highly effective pharmacologic therapies for osteoporosis, fracture rates in the United States have plateaued or increased in recent years.
Approach to the patient with low-risk thyroid cancer.
Three patients diagnosed with low-risk differentiated thyroid cancer were presented to illustrate the management options available.
Macroprolactinemia as a diagnostic pitfall in hyperprolactinemia: a systematic review and quantitative synthesis.
This systematic review analyzed 45 studies involving 2853 cases of macroprolactinemia among patients with hyperprolactinemia.
Thyroid-joint crosstalk: a systematic review and meta-analysis of thyroid autoimmunity and dysfunction in juvenile idiopathic arthritis.
This systematic review and meta-analysis examined the prevalence of thyroid autoantibody positivity and dysfunction in 19,015 children with juvenile idiopathic arthritis (JIA).
Approach to the patient: cases of hormonal management in older transgender and gender diverse adults.
This article presents a case-based approach to managing older transgender and gender diverse (TGD) adults undergoing gender-affirming hormone therapy.
Pancreatic fat and the risk of future dysglycemia: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the association between pancreatic fat and future dysglycemic outcomes, including type 2 diabetes (T2D) and glycemic progression.
Digenic HNF1A and ABCC8 variants provide mechanistic insight into early-onset diabetes.
Oligogenic inheritance in maturity-onset diabetes of the young (MODY) remains poorly characterized, and the contribution of multiple candidate variants to disease pathogenesis is incompletely understood.
Insights from changes in NDEV biomarkers of metabolism: effects of PPARγ and GLP1 receptor agonists on brain metabolism.
This randomized controlled trial examined the effects of pioglitazone (PPARγ agonist) and liraglutide (GLP1 receptor agonist) on central nervous system insulin signaling in participants with unremitted depression and…
Effects of testosterone-augmented multimodal exercise intervention in spinal cord injury: a randomized controlled trial.
This randomized controlled trial evaluated the effects of a home-based multimodal exercise intervention combining functional electrical stimulation-assisted leg cycling, arm ergometry, and testosterone in 84 adults with…
Hypothalamic-Pituitary Axis Involvement in Primary Central Nervous System Lymphoma.
This systematic review examined endocrine dysfunction related to the hypothalamic-pituitary axis in 99 adult patients with primary central nervous system lymphoma (PCNSL).
Cardiovascular and renal outcomes of GLP-1 receptor agonists in type 2 diabetes mellitus: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on cardiovascular outcomes in 83,004 patients with type 2 diabetes mellitus (T2DM).
Sodium-glucose cotransporter 2 inhibitors across cardio-reno-metabolic disease and body mass index: a meta-analysis of randomized controlled trials.
This meta-analysis of randomized controlled trials evaluated the impact of sodium-glucose cotransporter 2 inhibitors (SGLT2i) on cardiovascular and all-cause mortality across different body mass index (BMI) categories…
Machine learning identifies microbiome and clinical predictors of sustained weight loss following prolonged fasting.
This randomized controlled trial investigated the effects of a 5-day fasting intervention on body composition and gut microbiome in 38 healthy adults, with follow-up at 12 weeks.
Approach to the patient: precision medicine-guided evaluation and treatment of acromegaly.
Acromegaly is a heterogeneous disease in which delayed biochemical control remains common despite the availability of multiple therapeutic options.
Comparative efficacy of exercise and nutritional interventions on serum IGF-1 levels in older adults with frailty and/or sarcopenia: A systematic review and network meta-analysis.
This systematic review and frequentist random-effects network meta-analysis compared exercise, nutritional supplementation, and combined interventions for serum IGF-1 in older adults with sarcopenia and/or frailty.
Weight Reduction Heterogenicity and Mediators of GLP-1RAs and Dual Agonists for Individuals With Obesity: A Meta-Analysis.
This meta-analysis examined the weight loss effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) and dual agonists in 40,408 participants across 32 trials.
Maxillary brown tumour as the initial presentation of primary hyperparathyroidism.
A middle-aged woman presented with right cheek swelling due to an expansile maxillary lesion, initially misdiagnosed as a giant cell tumour.
Men's experiences of multiple long-term conditions and/or disability in the UK Game of Stones weight management trial: a mixed-methods evaluation.
This mixed-methods evaluation within the Game of Stones randomized controlled trial examined the experiences and health outcomes of 585 men with obesity, focusing on those with multiple long-term conditions (MLTCs)…
Pheochromocytoma Masquerading as Acute Coronary Syndrome Complicated by Cardiogenic Shock: A CARE-Compliant Case Report.
A 59-year-old man with a history of intermittent chest tightness presented with acute cardiogenic shock, elevated troponin levels, and reduced left ventricular ejection fraction.
Effects of 12 weeks of resistance and concurrent training with graded protein intakes on lipid profile, kidney and liver biomarkers in middle-aged to older women.
This randomized controlled trial investigated the effects of varying protein intakes during resistance training (RT) and concurrent training (CT) on lipid profiles and biomarkers in 108 middle-aged to older women.
Pharmacological therapies for the prevention of fractures in men.
This systematic review and meta-analysis evaluated the effectiveness of pharmacological therapies for fracture prevention in men aged 50 and older, focusing on bisphosphonates, PTH analogues, denosumab, and romosozumab.
Efficacy and safety of orforglipron 12 mg versus orforglipron 36 mg maintenance dose among patients with obesity with or without diabetes: a systematic review and comprehensive meta-analysis.
This systematic review and meta-analysis evaluated the efficacy and safety of orforglipron 12 mg versus 36 mg in 3459 obese adults, with or without diabetes.
Efficacy and safety of avexitide for treatment of hypoglycemia following bariatric and other upper gastrointestinal surgeries: a phase 2b study.
This phase 2b randomised controlled study evaluated avexitide in adults with clinically important hypoglycemia after Roux-en-Y gastric bypass, sleeve gastrectomy, total gastrectomy, or Nissen fundoplication.
Chronic hypophosphatemia leading to the diagnosis of autosomal recessive hypophosphatemic rickets type 2 caused by a novel pathogenic variant in ENPP1.
Two brothers in their late 40s presented with chronic hypophosphatemia and elevated serum parathyroid hormone (PTH) levels.
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