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782 articles
September 202624
Acute oral Chagas disease following armadillo blood ingestion: a case report.
A 70-year-old man from rural Colombia presented with atrial fibrillation, dyspnea, and palpitations. A blood smear identified Trypanosoma cruzi, confirmed by molecular testing, linked to his ingestion of armadillo blood…
Possible correlation between Mycobacterium abscessus subsp. massiliense spondylodiscitis and spinal anesthesia: Diagnostic and therapeutic challenges.
A 57-year-old man experienced back pain following spinal anesthesia for prostate surgery. Six months later, he underwent decompressive laminectomy, with initial cultures negative for mycobacteria.
Sequential combination of anti-PD-1 antibody and PEG-IFNα in chronic hepatitis B patients: correlates of HBsAg loss with enhanced T-cell responses.
This pilot clinical trial investigated the sequential combination of anti-PD-1 antibody (sintilimab) and PEG-IFNα in ten virologically suppressed chronic hepatitis B patients.
Losartan with add-on spironolactone for severe COVID-19 in the intensive care unit: a randomized controlled trial.
This randomized, open-label, parallel-group trial at five intensive care units in Marseille evaluated losartan, with conditional spironolactone, added to standard care for adults with severe COVID-19-related respiratory…
Associations Between Gut Microbiota and Immune Profiles in Community-Dwelling Older Adults and the Regulatory Role of Polygonatum odoratum.
This randomized controlled trial investigated the effects of Polygonatum odoratum on gut microbiota and immune profiles in 140 community-dwelling older adults aged 60 and above over 90 days.
Recurrent hydronephrosis and catheter blockage, secondary to an organised bacterial mass within the bladder.
An elderly man with a history of chronic kidney disease and a long-term catheter presented with urosepsis and recurrent catheter blockages.
A case of membranous nephropathy during asymptomatic syphilis.
A 51-year-old woman presented with weight gain and leg edema, leading to a diagnosis of nephrotic syndrome. Laboratory tests revealed low serum protein and heavy proteinuria.
Surveillance of antibiotic-resistant bacteria integrating whole genome sequencing and epidemiological information - a global, systematic review, 2012-2023.
This systematic review examined global surveillance systems for antibiotic-resistant bacteria (ARB) integrating whole genome sequencing (WGS) and epidemiological data.
Advanced Eumycetoma of the Right Foot Resulting in Below-Knee Amputation in Somalia: A Case Report.
A 33-year-old man from Somalia presented with a seven-year history of progressive swelling in the right foot, characterized by massive tumefaction and multiple discharging sinuses containing black grains.
Asymptomatic tuberculosis among household contacts of active pulmonary tuberculosis cases: a systematic review and meta-analysis.
This systematic review and meta-analysis estimated the prevalence of asymptomatic tuberculosis (TB) among household contacts of people with active pulmonary TB.
Safety and Immunogenicity of a PD-1-Enhanced HIV-1 Therapeutic DNA Vaccine: A Randomized, Double-Blind, Placebo-Controlled, Dose-Escalating Phase I Clinical Trial in People With HIV-1 on Antiretroviral Therapy.
This randomized, double-blind, placebo-controlled phase I trial evaluated the safety and immunogenicity of ICVAX™, a PD-1-enhanced HIV-1 therapeutic DNA vaccine, in 45 adults with HIV-1 on antiretroviral therapy.
Switching to Daily Doravirine/Islatravir (100/0.25 mg) Maintains Viral Suppression Through Week 48 Despite Baseline Non-Nucleoside Reverse Transcriptase Inhibitor Resistance-Associated Mutations or M184I/V in Proviral DNA.
This phase III clinical trial evaluated the effects of baseline resistance-associated mutations (RAMs) on the virologic response to doravirine/islatravir (DOR/ISL) in 1227 virologically suppressed adults with HIV-1.
In Host Mutational Adaptation of Mycobacterium Tuberculosis Complex Strains During Tuberculosis Infection.
This meta-analysis examined 5882 Mycobacterium tuberculosis complex (MTBC) genomes from 1044 patients to identify mutations associated with drug resistance during tuberculosis infection.
Effect of Delayed Antiretroviral Therapy Initiation on Anti-CD4 Autoantibodies in Antiretroviral Therapy-Naive People With HIV.
This randomized controlled trial investigated the effect of delayed antiretroviral therapy (ART) initiation on anti-CD4 autoantibodies in ART-naive individuals with HIV and CD4 > 500 cells/µL.
First Report on Remdesivir Use for the Treatment of Respiratory Syncytial Virus in Five Allogeneic Hematopoietic Cell Transplant Recipients.
Five allogeneic hematopoietic cell transplant recipients presented with lower respiratory tract infections caused by respiratory syncytial virus (RSV).
Pharmacokinetics and Dose Optimization of Ethambutol in Children on First-Line Antituberculosis Therapy: An Individual Patient Data Meta-Analysis.
This meta-analysis examined the pharmacokinetics of ethambutol (EMB) in 220 children aged 0.2-15 years undergoing first-line tuberculosis therapy.
Serotype-specific Immunity and Association With Pneumococcal Carriage Following 3+1, 3+0, and 2+1 Schedules of 10-valent Pneumococcal Conjugate Vaccine.
This phase II/III randomized controlled trial in Vietnam evaluated the relationship between serotype-specific memory B cells, IgG, and opsonophagocytic responses following different schedules of the 10-valent…
Isolated Ovarian Tuberculosis Mimicking Ovarian Malignancy in a Young Female with Primary Infertility: A Case Report.
A 23-year-old Afghan woman with primary infertility presented with pelvic pain and prolonged low-grade fever. She underwent laparotomy due to suspected ovarian malignancy, revealing bilateral ovarian cysts.
Candida tropicalis in environmental and animal reservoirs: a systematic review from a One Health perspective.
This systematic review examined Candida tropicalis in environmental and animal sources, synthesizing evidence on antifungal susceptibility, virulence-associated traits, and resistance mechanisms.
Discovery of mpox virus nucleic acid in bile: a case with multiple coinfections.
A patient with advanced HIV and multiple coinfections, but no rash, had Monkeypox virus (MPXV) nucleic acid detected in bile.
Rare ophthalmic complication of tuberculosis meningitis: tuberculosis orbital apex syndrome.
A woman in her mid-60s presented with orbital apex syndrome, characterized by dysfunction of multiple cranial nerves. Diagnostic challenges arose due to the rarity of tuberculosis-related OAS in non-endemic regions.
Pneumocystis jirovecii pneumonia in a non-HIV immunocompromised patient presenting with bilateral pneumothoraces.
A non-HIV immunocompromised patient developed Pneumocystis jirovecii pneumonia (PJP) after prolonged corticosteroid therapy, initially presenting with dyspnoea and fever.
Culture-positive left shoulder septic arthritis with suspected contralateral involvement secondary to Staphylococcus aureus bacteraemia.
An elderly diabetic patient presented with bilateral shoulder pain and elevated inflammatory markers, but without fever, erythema, swelling, or warmth, which are typical signs of septic arthritis.
An Ovarian Hydatid Cyst in a Woman with Hepatic and Pulmonary Echinococcosis.
A 27-year-old woman presented with nonspecific symptoms leading to the diagnosis of an ovarian hydatid cyst, which is a rare occurrence.
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