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406 articles
August 202624
Effects of diabetes, obesity, and metabolic syndrome on alcohol-associated liver disease: A systematic review.
This systematic review evaluated the impact of cardiometabolic risk factors (CMRFs) on clinical outcomes in adults with alcohol-associated liver disease (ALD).
Food intake sequence affects postprandial metabolic, hormonal, and appetite responses in healthy male football players: A randomised crossover trial.
This randomized crossover trial examined the effects of food intake sequence on postprandial responses in 14 highly trained male football players.
Severe Disseminated Melioidosis with Pulmonary, Cutaneous, and Osteoarticular Involvement in the Peruvian Amazon.
A 35-year-old man with poorly controlled diabetes living in the Peruvian Amazon presented with multifocal pneumonia, bacteremia, and septic shock requiring mechanical ventilation and vasopressors.
Association Between Follow-Up Mean Blood Pressure and Blood Pressure Control: A Meta-Regression Analysis of 101 Randomized Trials.
This meta-regression analysis examined the relationship between mean blood pressure (BP) and BP control in 101 randomized trials involving over 85,000 participants.
Programmatic effectiveness of tuberculosis preventive treatment for people with HIV in six high-tuberculosis-burden countries (PROTECT): a prospective cohort study and meta-analysis.
This prospective cohort study and meta-analysis evaluated the effectiveness of tuberculosis preventive treatment (TPT) in reducing tuberculosis incidence and all-cause mortality among 235,424 people with HIV initiating…
Toward a standardized framework for chronic obstructive pulmonary disease self-care: An umbrella review.
This umbrella review synthesized international COPD guidelines and systematic reviews to define core components of COPD self-care and assess their alignment with guidance.
Shared Decision-Making and the Role of Maternalism in Resolving Difficult End-of-Life Decisions.
We explore the spectrum of shared decision-making, especially the idea of maternalism, which combines patient or surrogate preferences and goals with the clinician's responsibility to provide care within the boundaries…
Virological reactivation of the hepatitis B virus after simplification of antiretroviral treatment.
Two patients living with HIV and isolated anti-HBc positivity experienced hepatitis B virus (HBV) reactivation after simplifying their antiretroviral therapy (ART) to regimens without anti-HBV activity.
Efficacy and safety of pantoprazole for stress-ulcer prophylaxis in critically ill patients: A systematic review and Meta-analysis of randomized controlled trials.
This systematic review and meta-analysis evaluated the efficacy and safety of pantoprazole for stress-ulcer prophylaxis in critically ill patients, including both adults and children.
Acute effects of interrupting prolonged sitting with short bouts of physical activity on postprandial metabolism in sedentary adults: A multi-level meta-analysis.
This systematic review and meta-analysis of randomised cross-over trials assessed acute effects of short activity breaks during prolonged sitting on postprandial metabolism in sedentary adults.
Cardiometabolic Renal Health Profile, Intensive Blood Pressure-Lowering Treatment and Cognitive Dysfunction: A Post Hoc Analysis of the SPRINT Trial.
This post hoc analysis of the randomised SPRINT trial examined whether baseline cardiometabolic renal health profiles modified cognitive outcomes with intensive blood pressure lowering.
Interventions with a significant mortality difference in acute respiratory distress syndrome: A systematic review and comparison with Guidelines.
This systematic review analyzed 33 randomized controlled trials (RCTs) to compare interventions with significant mortality differences in acute respiratory distress syndrome (ARDS) against European and American…
suPAR as a circulating inflammatory biomarker: time for translation into clinical practice - A systematic review.
This systematic review examines soluble urokinase-type plasminogen activator receptor (suPAR) as a circulating biomarker, its isoforms, and methods used to measure it.
Analytical interference by IgM paraprotein causing platform-dependent electrolyte discrepancies: a case-based laboratory investigation.
An 85-year-old man presented with low back pain, and laboratory tests revealed significant discrepancies in serum electrolyte and calcium measurements between two platforms.
Managing HIV in the extreme: Viral load and drug monitoring in a patient with BMI > 60 on long-acting cabotegravir/rilpivirine therapy.
A morbidly obese patient with a BMI of 62 kg/m² and a history of poor adherence to oral antiretroviral therapy presented with unsuppressed HIV viral load.
Exploring the scope and efficacy of nurse navigators in the care of individuals with complex care needs associated with chronic conditions: A systematic review.
This mixed-method systematic review examined the scope and efficacy of nurse navigators for people with complex care needs associated with chronic conditions.
The impact of acute sleep fragmentation on muscle blood flow responses to handgrip exercise.
This randomized crossover trial examined the effects of acute sleep fragmentation on muscle blood flow during exercise in 20 adults. Following fragmented sleep, brachial artery dilation decreased (5.5 ± 4.8% vs.
Rethinking Muscle Wasting in Critical Illness: A Systematic Review and Meta-Analysis of Myofiber Size and Protein Turnover.
This systematic review and meta-analysis examined skeletal muscle dysfunction in adults with critical illness, analyzing myofiber size and protein turnover.
Lifestyle modifications in individuals with blood pressure beyond treatment target despite pharmacological treatment: design and baseline characteristics of the MeDiPA randomised controlled trial.
The MeDiPA randomized controlled trial investigates the effects of lifestyle modifications on blood pressure in patients with uncontrolled hypertension despite pharmacological treatment.
The effect of metformin on the pharmacokinetics of rifampicin, isoniazid, and pyrazinamide in adults with tuberculosis.
This randomized controlled trial investigated the impact of metformin on the pharmacokinetics of rifampicin, isoniazid, and pyrazinamide in HIV/TB-coinfected adults without diabetes.
An expanded breakfast buffet increases daily energy and protein intakes in hospitalised patients: A prospective crossover quality improvement study.
This randomized controlled trial evaluated the impact of an expanded breakfast buffet on daily energy and protein intakes in hospitalized patients.
Efficacy of cannabinoids for insomnia and sleep disturbance: A systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis evaluated the efficacy of cannabinoids for insomnia in 2134 adults across ten randomized controlled trials.
Targeted Temperature Management at 35°C vs. 37°C for Heatstroke in ICU: A Pilot Randomized Controlled Trial.
This pilot multicenter randomized controlled trial evaluated targeted temperature management (TTM) at 35°C versus 37°C in 35 intubated heatstroke patients in ICUs across China.
Interventions to improve viral suppression and adherence to antiretroviral therapy among people living with HIV: a systematic review and network meta-analysis.
This systematic review and network meta-analysis evaluated adherence interventions for antiretroviral therapy among people living with HIV in low- and middle-income countries.
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