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433 articles
August 202624
Secondary Hemophagocytic lymphohistiocytosis in an immunocompetent adult: a case report distinguishing sarcoidosis from histoplasmosis.
A 73-year-old immunocompetent male presented with lethargy and poor oral intake, initially diagnosed with sarcoidosis. Clinical evaluation revealed fever, splenomegaly, pancytopenia, and elevated inflammatory markers.
SHR-2004, a Humanized Monoclonal Antibody Targeting Factor XI, for Preventing Venous Thromboembolism After Ovarian Cancer Surgery: A Randomized, Active-Controlled Phase 2 Study.
This multicenter, open-label, randomized Phase 2 trial compared the factor XI-targeting antibody SHR-2004 with enoxaparin followed by rivaroxaban for postoperative venous thromboembolism (VTE) prevention in patients…
Acute development of EBV+ T-cell lymphoproliferative disorder after treatment with rituximab for follicular lymphoma.
An elderly patient developed an EBV-positive T-cell lymphoproliferative disorder (LPD) following treatment with rituximab for follicular lymphoma.
Consolidation Therapy Based on Mutation Clearance in Acute Myeloid Leukemia.
This phase II multicenter trial evaluated the impact of leukemia-associated mutation (LAM) clearance on relapse-free survival (RFS) in 100 patients aged 18-60 with intermediate-risk acute myeloid leukemia (AML) in first…
Fecal filtrate transplantation as salvage therapy for fulminant Clostridioides difficile infection in adult hematological patients during chemotherapy-induced aplasia: a pilot experience.
Fulminant Clostridioides difficile infection (CDI) in patients with hematologic malignancies during chemotherapy-induced aplasia carries high mortality and limited treatment options.
ERG and CD31 expression in acute megakaryoblastic leukemia and myeloid sarcoma: A diagnostic pitfall.
A case of acute megakaryoblastic leukemia (AMKL) presented as a soft tissue mass was misdiagnosed as composite hemangioendothelioma due to the co-expression of ERG and CD31.
Indirect treatment comparisons find enhanced effectiveness of pegcetacoplan versus crovalimab in both complement inhibitor-naïve and -experienced patients with paroxysmal nocturnal hemoglobinuria.
This Phase III randomized controlled trial evaluated the effectiveness of pegcetacoplan versus crovalimab in patients with paroxysmal nocturnal hemoglobinuria (PNH), both C5 inhibitor-naïve and experienced.
Raccoon eye as the sole presenting sign of AL amyloidosis associated with a low-burden clonal plasma cell neoplasm.
A 60-year-old woman presented with recurrent periorbital purpura, known as 'raccoon eyes,' as the sole clinical manifestation.
Gelatinous transformation and concomitant fibrosis of bone marrow in a patient with relapsed myelodysplastic syndrome following unrelated bone marrow transplantation.
A 69-year-old woman with myelodysplastic syndrome (MDS) underwent unrelated bone marrow transplantation and initially achieved complete remission.
Multifocal Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type, Presenting on Face and Chest: Complete Remission With R-CHOP.
A 79-year-old woman developed rapidly enlarging erythematous-to-violaceous tumors and plaques on her face, chest, left upper arm, and upper back.
Risk of post-acute symptoms and conditions after SARS-CoV-2 compared with other respiratory viral infections: a systematic review and meta-analysis.
This systematic review and meta-analysis compared persistent symptoms and conditions in adults after SARS-CoV-2 infection with those following other acute respiratory viral infections.
Second umbilical cord blood transplantation for relapsed adverse-risk acute myeloid leukemia patient with near-homozygous HLA haplotypes.
A patient with adverse-risk acute myeloid leukemia (AML) and near-homozygous HLA haplotypes underwent double units unrelated umbilical cord blood transplantation (dUCBT) twice.
Prevalence and risk factors of red blood cell alloimmunization among sickle cell disease patients in resource-limited countries: A systematic review and meta-analysis.
This systematic review and meta-analysis examined the prevalence and risk factors of red blood cell alloimmunization among sickle cell disease patients in low- and lower-middle-income countries.
Emergent Reversal of Intracranial Hemorrhage Using 4-Factor Prothrombin Complex Concentrate in a Pediatric Patient.
An 11-year-old male with sinusitis complicated by multifocal intracranial abscesses and a superior sagittal sinus thrombus was treated with rivaroxaban.
Early red blood cell transfusion strategy in septic shock among patients with cancer: the TRANSPORT randomized controlled trial.
The TRANSPORT trial investigated red blood cell transfusion strategies in 187 cancer patients with septic shock. Patients were assigned to either a liberal or restrictive transfusion strategy.
Dulaglutide vs insulin in adolescents with thalassaemia-induced diabetes: effect on metabolism and atherogenesis (DIADEMA).
The DIADEMA trial compared dulaglutide to insulin in adolescents (10-18 years) with thalassaemia-induced diabetes. After 24 weeks, dulaglutide significantly reduced glycaemic variability (CV decreased from 39.45% to…
Intravascular Large B-Cell Lymphoma After Kidney Transplantation: A Rare Form of Post-Transplant Lymphoproliferative Disorder.
A Japanese man in his 60s developed intravascular large B-cell lymphoma (IVLBCL) 4.5 years after kidney transplantation, presenting with general fatigue and loss of appetite.
Concomitant lipid-lowering and anticoagulation therapy for recurrent venous thromboembolism prevention: A Bayesian meta-analysis.
This Bayesian meta-analysis evaluated the efficacy and safety of combined lipid-lowering therapy (LLT) and anticoagulation (AC) for preventing recurrent venous thromboembolism (rVTE) in 28 studies, including 11…
Association between the interleukin 17F rs763780 polymorphism and immune thrombocytopenia risk: A systematic review and meta-analysis.
This meta-analysis examined the association between the interleukin 17F rs763780 polymorphism and immune thrombocytopenia (ITP) risk, analyzing data from eight case-control studies with 805 ITP cases and 841 controls.
Disseminated Ganciclovir-Resistant Cytomegalovirus in a Nontransplant Pediatric ALL Patient: A Case Report.
An 8-year-old patient with T-ALL on maintenance chemotherapy developed significant CMV viremia without initial end-organ disease, which progressed to ganciclovir-resistant CMV infection.
Analytical interference by IgM paraprotein causing platform-dependent electrolyte discrepancies: a case-based laboratory investigation.
An 85-year-old man presented with low back pain, and laboratory tests revealed significant discrepancies in serum electrolyte and calcium measurements between two platforms.
A Rare BCR::SPECC1L::ABL1 Fusion in a Pediatric Chronic Myeloid Leukemia Patient.
An 8-year-old girl diagnosed with chronic myeloid leukemia (CML) presented with a typical Philadelphia chromosome and BCR::ABL1 fusion identified through karyotyping and FISH.
Secondary Hemophagocytic Lymphohistiocytosis Triggered by Mixed Plasmodium spp. and SARS-CoV-2 Coinfection.
A patient with mixed Plasmodium vivax and P. falciparum malaria acquired in Mato Grosso, Brazil, and concomitant SARS-CoV-2 infection presented in nonendemic Macaé with high fever and pancytopenia.
Secretory Phospholipase A 2 in Patients With Sickle Cell Disease Hospitalized for Vaso-Occlusive Pain Episodes.
This randomized controlled trial evaluated plasma levels of secretory phospholipase A 2 (sPLA 2) in 105 pediatric patients with sickle cell disease hospitalized for vaso-occlusive pain episodes.
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