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72 articles
October 202613
Novel Imaging Techniques Prior to Surgical Management of Invasive Bladder Cancer: A Systematic Review.
This PRISMA-guided systematic review assessed novel imaging for detecting muscle invasion and nodal disease before surgical management of invasive bladder cancer. It included 33 studies encompassing 4,689 patients.
Multicenter Phase I Study of Triapine in Combination with [177Lu]Lutetium-Dotatate in Patients with Well-Differentiated Neuroendocrine Tumors (ETCTN 10388).
This multicenter phase I dose-escalation and dose-expansion study evaluated [177Lu]lutetium-dotatate plus oral triapine in patients with well-differentiated gastroenteropancreatic neuroendocrine tumors.
A Phase I Dose-Escalation/Expansion Study of Fractionated-Dose and Multiple-Cycle Anti-PSMA-Targeted α-Emitter 225Ac-J591 in Patients with Prostate Cancer.
This phase I dose-escalation and expansion study evaluated fractionated and repeated-cycle 225Ac-J591 in patients with progressive metastatic prostate cancer resistant to androgen pathway modulation.
Volumetric discordance between ¹⁸F-FET-PET/MRI and MRI-based radiotherapy target volumes in high-grade glioma: a prospective pilot study (FETSMaRT).
This prospective pilot study enrolled 30 patients with WHO grade 3 or 4 high-grade glioma receiving postoperative radiotherapy.
68Ga-DOTATATE PET/CT Detection of Hypertrophic Osteoarthropathy in a Pediatric Patient With Neuroblastoma Following Anti-GD2 Immunotherapy.
A 5-year-old boy with high-risk neuroblastoma underwent 68Ga-DOTATATE PET/CT to assess response after anti-GD2 immunotherapy.
Amyloid PET Quantitation and Centiloid Thresholds in the Diagnosis of Alzheimer Disease: An Individual Participant Data Meta-Analysis.
This individual participant data meta-analysis examined amyloid PET scans from 49,227 participants across 53 studies to establish Centiloid positivity cutoffs for Alzheimer disease diagnosis.
Primary pulmonary mucosa-associated lymphoid tissue lymphoma presenting as a right hilar mass: A case report.
A 44-year-old male presented with an incidental right hilar mass discovered during routine screening. He was asymptomatic, and imaging revealed a 3.9 × 3.5 cm mass causing bronchial compression and post-obstructive…
Clinical Trial Protocol for LPS-Boost: Intensified [ 177 Lu]Lu-PSMA-617 Treatment for Patients with Metastatic Castration-Resistant Prostate Cancer with Low PSMA-Expressing Disease.
This multicenter, open-label phase 2 trial investigates an intensified treatment schedule of [177Lu]Lu-PSMA-617 for 45 patients with metastatic castration-resistant prostate cancer (mCRPC) and low PSMA expression.
Tumor and Organ Dose Estimates from 177 Lu-PSMA-617 Therapy in Patients with Metastatic Castration-Resistant Prostate Cancer: Results from the RESIST-PC Phase 2 Trial.
The RESIST-PC Phase 2 trial assessed dosimetry of [177Lu]Lu-PSMA-617 in patients with metastatic castration-resistant prostate cancer. A total of 48 patients were analyzed, receiving either 6.0 or 7.4 GBq per cycle.
A Phase 2, Open-Label, Randomized Controlled Trial Evaluating Safety and Efficacy of Dose-Intensified Versus Standard Dosing Regimens of [ 177 Lu]Lu-PSMA-597 in mCRPC (OPTIMAL-PSMA).
The OPTIMAL-PSMA study is a Phase 2, open-label, randomized controlled trial evaluating the safety and efficacy of a dose-intensified regimen of [177Lu]Lu-PSMA-597 versus standard dosing in 120 patients with metastatic…
First-in-Human, Open-label, Single-Arm Phase I Study of [211At] meta-Astatobenzylguanidine in Patients with Pheochromocytoma or Paraganglioma.
This first-in-human, open-label, single-arm Phase I study evaluated the safety and pharmacokinetics of 211At-meta-astatobenzylguanidine (211At-MABG) in 10 patients with unresectable or metastatic pheochromocytomas or…
Follow-Up 18F-Fluorodeoxyglucose Positron Emission Tomography in Treated Patients With Giant Cell Arteritis: A Systematic Review and Metaanalysis.
This systematic review and meta-analysis evaluated the use of 18F-fluorodeoxyglucose (FDG) PET to monitor disease activity in patients with large-vessel giant cell arteritis (LV-GCA) who showed clinical improvement…
[18F]RCCB6 PET/CT in Diagnosing Clear-Cell Renal Cell Carcinomas: A Prospective Comparison Study with [18F]FDG PET/CT and Conventional Imaging.
[18F]RCCB6 PET/CT was evaluated in a single-center phase II trial for detecting metastases in clear-cell renal cell carcinoma (ccRCC).
September 202611
First systematic mapping of non-target [68Ga]Ga-DOTANOC uptake across anatomical sites and etiologies.
This systematic review analyzed 76 studies involving 542 patients to map non-target [68Ga]Ga-DOTANOC uptake across various anatomical sites and etiologies.
Evaluating the Clinical Utility of TSPO-PET in MS and the Influence of Methodological Heterogeneity: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated TSPO-PET imaging in multiple sclerosis (MS) patients compared to healthy controls.
Unusual pelvic mass in a young adult: prostatic Ewing's sarcoma with distant metastases.
A man in his 20s presented with urinary obstruction, constipation, and leg pain. Imaging revealed a bulky pelvic mass from the prostate, leading to bilateral hydroureteronephrosis.
Reversing the Reverse: Nitrate-Enhanced Tc-99m MIBI MPS Unmasking Microvascular Dysfunction in Takayasu Arteritis.
Takayasu Arteritis (TA) is a large vessel vasculitis involving the aorta and its major branches, which could be complicated by significant cardiovascular manifestations.
Clinical utility of DaTscan in clinically uncertain parkinsonian syndromes: a systematic review and meta‑analysis.
This systematic review and meta-analysis assessed how often DaTscan (123I-ioflupane SPECT) was followed by a diagnostic change in patients with clinically uncertain parkinsonian syndromes.
Dosimetric and therapeutic effectiveness of high-dose-rate radionuclide sources in breast cancer brachytherapy: A systematic review.
This systematic review compared dosimetric properties and therapeutic evidence for ¹⁹²Ir, ⁶⁰Co, and ¹⁶⁹Yb in high-dose-rate breast cancer brachytherapy.
Brain serotonin transporter remains stable across seasons: A Bayesian and frequentist meta-analysis.
This meta-analysis examined seasonal variations in brain serotonin transporter (SERT) availability in healthy individuals using neuroimaging studies.
Validation of the newly introduced Deauville score 5a for patients treated for advanced-stage classic Hodgkin lymphoma.
This randomized controlled trial evaluated the prognostic value of the newly defined Deauville score 5a in patients with advanced-stage classical Hodgkin lymphoma (AS-cHL) after two cycles of treatment.
Pregnancy in a patient with metastatic functioning midgut neuroendocrine tumor receiving lanreotide after peptide receptor radionuclide therapy.
A pregnant patient with a metastatic neuroendocrine tumor of the ileocecal valve and carcinoid syndrome was treated with lanreotide after undergoing peptide receptor radionuclide therapy and debulking surgery.
Disproportionately Enlarged Subarachnoid Space Hydrocephalus (DESH) Identified on I-123 Ioflupane SPECT/CT.
A patient with gait instability underwent I-123-ioflupane SPECT/CT imaging for suspected Parkinson's disease. DaTQUANT analysis was negative for Parkinson's disease; however, evaluation of the SPECT images revealed low…
177 Lu-FAPI-2286 Radioligand Therapy in Refractory Scalp Melanoma.
A 66-year-old man with inoperable scalp melanoma that had not responded to immunotherapy was assessed for 177Lu-DOTATATE therapy.
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