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406 articles

July 202624

Clinical ResearchCardiologyOpen access

When Methods Matter: An Umbrella Review of Lorundrostat and the Impact of Analytical Decisions on Reported Blood Pressure and Safety Outcomes.

This umbrella review evaluated the effects of lorundrostat on blood pressure and hyperkalemia risk in adults with uncontrolled hypertension, synthesizing data from ten systematic reviews and meta-analyses.

Am J Cardiovasc DrugsJul 23, 2026Read summary
Clinical ResearchCardiology

Clinical Modifiers of Salt Sensitivity: A Meta-Regression and Risk Translation Study.

This meta-analysis examined the relationship between sodium intake and blood pressure across various clinical populations, analyzing 160 studies with 16,443 participants.

HypertensionJul 23, 2026Read summary
Clinical ResearchInternal Medicine (General)

Effects of nutritional therapy on morphofunctional outcomes in critically ill patients: A systematic narrative synthesis.

This systematic review examined the effects of nutritional therapy on morphofunctional outcomes in critically ill adult ICU patients.

Clin Nutr ESPENJul 23, 2026Read summary
Case ReportGastroenterologyOpen access

Severe pancreatic exocrine insufficiency presenting with hypoalbuminemia, anasarca, and pulmonary edema in a patient with prior gastrectomy and suspected immunoglobulin G4-related pancreatobiliary disease.

A 55-year-old man with prior subtotal gastrectomy presented with generalized edema, substantial weight gain, dyspnea, and frequent watery, pale stools.

Clin J GastroenterolJul 23, 2026Read case
Case ReportInfectious Diseases

Retroperitoneal infection associated with Streptococcus dysgalactiae subsp. equisimilis bacteremia and lower-extremity cellulitis: a case report.

A 70-year-old man with diabetes and alcoholic liver disease presented with fever and septic shock. Initial imaging revealed retroperitoneal lymphadenopathy and inflammatory changes, with subsequent identification of…

J Infect ChemotherJul 22, 2026Read case
Clinical ResearchNeurologyOpen access

Dyadic Capability in Stroke Survivors and Their Caregivers: A Systematic Review and Integrated Concept Analysis.

This systematic review and integrated concept analysis examined capability and related constructs in stroke survivors and their caregivers, with the aim of clarifying capability at the dyad level.

J Cardiovasc NursJul 22, 2026Read summary
Clinical ResearchInternal Medicine (General)

Herb-drug interactions with clinical impact: A systematic review of global clinical evidence on medicinal plants widely used in Ecuador.

This systematic review analyzed clinical evidence on herb-drug interactions involving medicinal plants commonly used in Ecuador.

J EthnopharmacolJul 21, 2026Read summary
Clinical ResearchPsychiatryOpen access

Effects of a brief primary care intervention for post-traumatic stress disorder symptoms after critical illness on health-related quality of life - A secondary analysis of the PICTURE randomised controlled trial.

This secondary analysis of the PICTURE randomised controlled trial evaluated the impact of a brief GP-delivered narrative exposure intervention on health-related quality of life (HRQoL) in 319 adult ICU survivors with…

Eur J Gen PractJul 21, 2026Read summary
Case ReportInfectious Diseases

Malignant syphilis with presumed multifocal osteomyelitis in a patient with human immunodeficiency virus: A case report.

A 37-year-old man with HIV presented with fever, weight loss, and a generalized rash featuring ulcerative lesions. Initial rapid plasma reagin testing was negative, but subsequent testing showed seroconversion.

J Infect ChemotherJul 21, 2026Read case
Clinical ResearchInternal Medicine (General)

The effect of foot positioning on tissue oxygenation in diabetic foot ulcers.

This randomized controlled trial assessed the impact of foot positioning on tissue oxygenation in 60 hospitalized patients with diabetic foot ulcers.

Diabetes Res Clin PractJul 21, 2026Read summary
Clinical ResearchInfectious DiseasesOpen access

Characterization of the Immune Response after Oral Cholera Vaccination (OCV) and Effects of Mycophenolate Mofetil on Priming of this Immune Response-A Randomized, Placebo-Controlled Trial.

This randomized, placebo-controlled trial examined the immune response to oral cholera vaccination (OCV) in 16 healthy volunteers, focusing on the effects of mycophenolate mofetil (MMF).

Clin Pharmacol TherJul 21, 2026Read summary
Clinical ResearchInternal Medicine (General)

Incidence and risk factors of refeeding syndrome in critically ill patients: A systematic review and meta-analysis.

This systematic review and meta-analysis evaluated the incidence and risk factors of refeeding syndrome (RFS) in critically ill patients, analyzing data from 49 studies with 24,778 participants.

Clin NutrJul 21, 2026Read summary
Clinical ResearchNeurologyOpen access

Akkermansia muciniphila enhances washed microbiota transplantation in the treatment of epilepsy.

This prospective, single-center cohort study evaluated the efficacy and safety of washed microbiota transplantation (WMT) in 21 patients with epilepsy, primarily those with refractory cases.

Chin Med J (Engl)Jul 20, 2026Read summary
Case ReportInternal Medicine (General)

The Challenges of Compassion Bias in Clinical Decision-Making: A Case-Based Ethical Analysis.

A young woman with advanced neurologic decline due to HIV-associated progressive multifocal leukoencephalopathy had artificial enteral nutrition initially deferred by clinicians.

J Pain Symptom ManageJul 20, 2026Read case
Clinical ResearchDermatology

Antimicrobial photodynamic therapy improves wound quality and tissue repair in diabetic foot ulcers: A randomized double blind controlled clinical trial.

This randomized controlled trial assessed the effects of antimicrobial photodynamic therapy (aPDT) on wound quality and tissue repair in patients with diabetic foot ulcers.

J Photochem Photobiol BJul 19, 2026Read summary
Clinical ResearchInfectious Diseases

Early clinical decision support using interpretable artificial intelligence in acute illness (sepsis and infection): A systematic review and meta-analysis.

This systematic review and meta-analysis evaluated the diagnostic and prognostic performance of interpretable AI models in sepsis and severe infections.

Int J Med InformJul 18, 2026Read summary
Clinical ResearchEndocrinology

Protocol for the CLOCKS study: A 4-arm randomized controlled trial testing the independent and combined effects of 2 chronotherapies-early time-restricted eating and daytime bright light therapy-in adults with type 2 diabetes.

The CLOCKS study is a 4-arm randomized controlled trial investigating the effects of early time-restricted eating (eTRE) and daytime bright light therapy (BLT) on glycemic control in 344 adults with type 2 diabetes.

Nutr ResJul 17, 2026Read summary
Clinical ResearchGeriatrics

Nurses' perceptions of hospital-acquired conditions in older adults in acute care settings: A randomized vignette-based study.

This randomized controlled trial explored nurses' perceptions of factors contributing to hospital-acquired conditions in older adults within acute care settings.

Geriatr NursJul 17, 2026Read summary
Clinical ResearchInternal Medicine (General)Open access

Effects on mortality of different blood purification techniques in sepsis patients: an umbrella review of systematic reviews and meta-analyses.

This umbrella review analyzed 42 systematic reviews and meta-analyses to assess the impact of various extracorporeal blood purification techniques on mortality in sepsis patients.

Ren FailJul 16, 2026Read summary
Case ReportCardiology

Cardioneural and accessory atrioventricular pathway ablation for vagally mediated atrial fibrillation in PRKAG2 syndrome.

A young patient with PRKAG2-mediated cardiomyopathy experienced refractory paroxysmal atrial fibrillation (AF) despite previous accessory atrioventricular pathway ablation.

Heart LungJul 16, 2026Read case
Clinical ResearchInternal Medicine (General)

Obesity paradox in sepsis: a systematic review and meta-analysis of short- and long-term mortality risks.

This systematic review and meta-analysis examined the relationship between elevated BMI and mortality in 130,755 adult sepsis patients.

Med Intensiva (Engl Ed)Jul 16, 2026Read summary
Clinical ResearchEndocrinology

Effect of walking training on blood glucose control and metabolic health in patients with type 2 diabetes: A systematic review and meta-analysis.

This systematic review and meta-analysis evaluated the impact of walking training on blood glucose control in 483 patients with type 2 diabetes.

Exp GerontolJul 15, 2026Read summary
Clinical ResearchOncology (Medical)

Outcomes at rapid diagnostic centres and the association between non-specific symptoms and cancer: A systematic review and meta-analyses of up to 21,392 patients.

This systematic review and meta-analysis evaluated the association between non-specific symptoms (NSSs) and cancer in up to 21,392 patients diagnosed through rapid diagnostic centres.

Cancer EpidemiolJul 15, 2026Read summary
Clinical ResearchEndocrinology

Association of intermuscular and intramuscular fat with insulin resistance, type 2 diabetes, and metabolic syndrome: A systematic review.

This systematic review examined the relationship between intermuscular and intramuscular fat and cardiometabolic risks, including insulin resistance, type 2 diabetes, and metabolic syndrome in adults.

Clin NutrJul 15, 2026Read summary

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