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751 articles
August 202624
Recent advances in polyendocrine metabolic ovarian syndrome, formerly polycystic ovary syndrome, with emphasis on endocrine and metabolic dysfunction and cardiovascular risk.
This systematic review discusses polyendocrine metabolic ovarian syndrome (PMOS), affecting 10%-13% of reproductive-age women, emphasizing its recognition as a lifelong endocrine and metabolic disorder.
Effects of semaglutide and empagliflozin on markers of endothelial function in persons with type 2 diabetes: A post hoc analysis of a randomized clinical trial.
This post-hoc analysis of a 32-week randomized trial evaluated the effects of semaglutide and empagliflozin on endothelial function markers in 120 participants with type 2 diabetes.
Heterogeneous associations of antidiabetic medications with cancer prognosis: Evidence from 61 studies with over 1.1 million patients.
This meta-analysis evaluated the prognostic effects of seven antidiabetic medication classes in over 1.1 million cancer patients, primarily with type 2 diabetes.
Effects of acute and short-term grape seed extract supplementation on blood pressure responses to exercise in individuals at cardiometabolic risk: A randomised, double-blind, placebo-controlled exploratory crossover trial.
This randomized, double-blind, placebo-controlled crossover trial examined the effects of grape seed extract (GSE) supplementation on blood pressure responses to exercise in ten sedentary adults with elevated blood…
Metabolic and macrovascular outcomes following simultaneous pancreas-kidney transplantation and kidney transplantation alone in recipients with type 1 diabetes mellitus: a systematic review and meta-analysis.
This systematic review and meta-analysis compared metabolic and macrovascular outcomes between simultaneous pancreas-kidney transplantation (SPKTx) and kidney transplantation alone (KTx) in adults with type 1 diabetes.
Machine learning prediction models for diabetic kidney disease: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated machine learning models for predicting diabetic kidney disease (DKD) across various studies.
Effect of diet macronutrient content on the cardiometabolic response to weight loss: A randomized clinical trial.
This randomized clinical trial examined the impact of different macronutrient compositions in diets on cardiometabolic responses to moderate weight loss in individuals with metabolically unhealthy obesity.
Image-Guided Thyroid Ablation versus Surgery for T1N0M0 Papillary Thyroid Carcinoma: A Consensus-Aligned Systematic Review and Meta-Analysis.
This systematic review and meta-analysis compared image-guided thyroid ablation (IGTA) with surgery for T1N0M0 papillary thyroid carcinoma (PTC).
ALG-055009 in non-cirrhotic adults with metabolic dysfunction-associated steatohepatitis (HERALD): a randomised, double-blind, placebo-controlled, phase 2a trial.
The HERALD study was a randomised, double-blind, placebo-controlled phase 2a trial of once-daily ALG-055009 in non-cirrhotic adults with presumed MASH and F1–F3 fibrosis.
Impact of Metformin Plus Lifestyle Intervention Compared With Lifestyle Intervention Alone on Prediabetes Remission in Participants With Impaired Glucose Regulation: The China DPP Study.
This secondary analysis of the multicentre, unblinded China Diabetes Prevention Program randomised trial compared metformin plus lifestyle intervention with lifestyle intervention alone in Chinese adults aged 18–70…
Gut microbial diversity at baseline conditions the clinical, microbiome, and metabolic response to paraprobiotic Lactiplantibacillus plantarum LRCC5282 in overweight adults.
This randomized controlled trial investigated the impact of baseline gut microbial diversity on the response to the paraprobiotic Lactiplantibacillus plantarum LRCC5282 in 120 overweight adults over 12 weeks.
Efficacy of dapagliflozin on hepatic steatosis and fibrosis in patients with type 2 diabetes mellitus and metabolic dysfunction-associated steatotic liver disease: a pre-specified single-arm analysis from a randomized controlled trial.
This study evaluated the effects of dapagliflozin on hepatic steatosis and fibrosis in patients with type 2 diabetes and metabolic dysfunction-associated steatotic liver disease (MASLD) over 12 months.
Closed-loop insulin delivery for glycaemic control in hospitalised and perioperative adults: A systematic review and meta-analysis of randomised controlled trials.
This systematic review and meta-analysis evaluated the impact of closed-loop insulin delivery on glycaemic control in hospitalised and perioperative adults.
Short Pancreas in Children With Fanconi Anemia: A Report of Three Cases.
Three children with Fanconi anemia presented with a short pancreas, characterized by the absence of the pancreatic tail, identified through computed tomography.
Lactose and sucrose each stimulate hepatic de novo lipogenesis: A randomized crossover trial.
This randomized crossover trial evaluated the effects of lactose on hepatic de novo lipogenesis (DNL) in 24 adults without obesity.
Cardiorespiratory and Metabolic Responses After Sleeve Gastrectomy in Adults With Obesity: Systematic Review.
This systematic review examined cardiorespiratory and metabolic responses after sleeve gastrectomy in adults with obesity. It included seven observational reports involving 162 participants from two independent cohorts…
Near-infrared Autofluorescence Probe Versus Visual Identification for Parathyroid Detection and Functional Preservation During Total Thyroidectomy: A Randomized Controlled Trial.
This single-center, prospective randomized trial compared PTeye-guided near-infrared autofluorescence with visual identification of parathyroid glands during first-time total thyroidectomy.
Assessment of the safety and efficacy of sodium pentaborate pentahydrate in individuals with overweight and obesity: a randomized, double-blind, placebo-controlled, phase 1/2 dose-finding trial.
This randomized, double-blind, placebo-controlled phase 1/2 trial evaluated the safety and preliminary efficacy of sodium pentaborate pentahydrate in 177 adults with overweight or obesity over 12 weeks.
A Novel Protocol for Pre-Treatment Diagnostic 131 I Scan Within 24 Hours Post-Second rhTSH Administration to Guide Radioiodine Therapy in Differentiated Thyroid Cancer.
This single-center, prospective clinical trial evaluated the feasibility of performing a diagnostic 131 I whole-body scan (Dx-WBS) within 24 hours after the second rhTSH injection in patients with differentiated thyroid…
Weight Loss Improves Predicted 10-Year MACE and Type 2 Diabetes Risk, but Benefits Partially Rebound at 1 Year.
This randomized controlled trial examined the effects of weight loss on predicted 10-year risks for major adverse cardiovascular events (MACE) and type 2 diabetes (T2D) in sedentary women with overweight.
Optimal dose and exercise modality to improve HbA1c in older adults with type 2 diabetes mellitus: a systematic review with pairwise, network, and dose-response meta-analyses.
This systematic review and meta-analysis evaluated the effects of various exercise modalities on HbA1c levels in older adults with type 2 diabetes mellitus.
Efficacy and safety of mazdutide in adults with obesity or overweight: a US-based, multicentre, phase 2, randomised, placebo-controlled clinical trial.
This 48-week, US-based, multicentre, randomised, double-blind, placebo-controlled phase 2 trial evaluated once-weekly mazdutide in adults with obesity or overweight and without type 2 diabetes.
Effects of breaking up prolonged sitting with light-intensity walking on postprandial glucose and lipid responses in sedentary adult men.
This randomized controlled trial compared two light-intensity walking-break schedules with uninterrupted sitting in 16 sedentary adult men during three 300-minute conditions.
Lipid Infusion Enhances Sympathetic Transduction via Redox-Sensitive Pathways.
This randomized controlled trial investigated the effects of intravenous lipid infusion on sympathetic-vascular transduction and arterial pressure variability in healthy adults.
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