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433 articles
June 202624
The clinical net benefit of venous thromboembolism prophylaxis in mild-risk thrombophilia and pregnancy: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the effectiveness of thromboprophylaxis in preventing venous thromboembolism (VTE) in 1320 pregnant women with mild-risk inherited thrombophilia.
Dordaviprone Maintenance After Allogeneic HCT for High-Risk Acute Myeloid Leukemia and Myelodysplastic Neoplasm.
This Phase I clinical trial evaluated the safety of dordaviprone maintenance therapy after allogeneic hematopoietic cell transplantation in 20 adults with high-risk acute myeloid leukemia (AML) or myelodysplastic…
Acquired haemophilia A diagnosed during preoperative evaluation for lung cancer surgery: A case report.
During preoperative assessment for lung tumour resection, a patient was found to have a prolonged activated partial thromboplastin time.
Further Support of Autosomal Recessive CSF3-Related Severe Congenital Neutropenia.
A patient with severe congenital neutropenia (SCN) was evaluated and found to have a homozygous pathogenic loss-of-function variant in the CSF3 gene.
Vitamin B12 Deficiency in Sickle Cell Disease: Method-Driven Estimates and Systematic Diagnostic Misclassification.
This systematic review assessed the prevalence of vitamin B12 deficiency in sickle cell disease (SCD) across 14 observational studies.
Disseminated Mucormycosis and monoclonal gammopathy in a young sarcoidosis patient following COVID-19: A rare case report.
A previously healthy 25-year-old male developed disseminated mucormycosis following COVID-19, alongside sarcoidosis and IgG-kappa monoclonal gammopathy.
Two cases of durvalumab-induced Evans syndrome in biliary tract cancer.
Two men aged 71 and 73 with advanced hilar cholangiocarcinoma developed Evans syndrome while receiving durvalumab monotherapy after eight cycles of gemcitabine, cisplatin, and durvalumab.
Unmanipulated Haploidentical Stem Cell Transplantation Outcome in a Pediatric Patient With CD27 Deficiency and EBV-Induced Diffuse Large B-Cell Lymphoma With Primary CNS Involvement.
A pediatric patient with CD27 deficiency developed EBV-associated diffuse large B-cell lymphoma with primary CNS involvement and experienced an early relapse.
Quality and Safety Intervention: Improving Care of Patients Undergoing B Cell-Targeted Therapies.
This review describes two illustrative cases involving patients receiving B cell-targeted therapies (BCTT). The abstract does not provide their individual presentations, test results, diagnoses, or outcomes.
Compound heterozygous variants in F7 gene causing severe factor VII deficiency without bleeding: A genotypic and laboratory analysis.
A patient with hereditary factor VII deficiency presented for planned renal cyst surgery. Preoperative tests showed prolonged prothrombin time and reduced factor VII activity, leading to surgery postponement.
Prognostic factors for patients with relapsed or refractory multiple myeloma who are initiating a fourth or later line car T-cell or bispecific antibody therapy: a systematic literature review and meta-analysis.
This systematic literature review and meta-analysis evaluated prognostic factors for patients with relapsed or refractory multiple myeloma undergoing fourth or later line CAR T-cell or bispecific antibody therapy.
An atypical RUNX1::ETV6::RUNX1 fusion in a pediatric patient with precursor B-cell acute lymphoblastic leukemia.
A 2-year-old male presented with precursor B-cell acute lymphoblastic leukemia (B-ALL) and was found to have an atypical RUNX1::ETV6::RUNX1 fusion.
Efficacy and Safety of the C3 Inhibitor Pegcetacoplan in Paroxysmal Nocturnal Hemoglobinuria: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the efficacy and safety of pegcetacoplan, a complement C3 inhibitor, in 271 patients with paroxysmal nocturnal hemoglobinuria (PNH).
Impact of early fresh frozen plasma administration on clinical outcomes in snakebite-induced coagulopathy: A systematic review.
This systematic review evaluated the impact of early fresh frozen plasma (FFP) administration alongside antivenom in patients with snakebite-induced coagulopathy.
The Changing Landscape of Maintenance Therapy in Newly Diagnosed Multiple Myeloma: A Systematic Review With Network Meta-Analysis of the European Myeloma Network (EMN).
This systematic review and network meta-analysis evaluated maintenance therapies for newly diagnosed multiple myeloma. It found that lenalidomide, proteasome inhibitors, and CD38 antibodies improved progression-free…
Diffuse Splenic Uptake on 99m Tc MDP Bone Scintigraphy Secondary to Transfusion-Related Hemosiderosis : Correlation With MRI Findings.
A 70-year-old woman with a past medical history of breast cancer is undergoing surveillance. She also had a history of repeated blood transfusions for refractory anemia caused by treated marrow metastatic disease.
Safety and Efficacy of Iron Chelators in Patients With Chronic Kidney Disease: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the efficacy and safety of iron chelators in adults with chronic kidney disease, analyzing data from 11 studies involving 206 patients.
Successful treatment of idiopathic multicentric Castleman disease with TAFRO and kidney involvement: case report and literature review.
A patient with idiopathic multicentric Castleman disease (iMCD-TAFRO) presented with acute kidney failure, characterized by severe renal dysfunction and other systemic symptoms.
Influenza as a Less Commonly Recognized Cause of Hemophagocytic Lymphohistiocytosis: A Systematic Review of Case Reports and Case Series.
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyper-inflammatory condition that can be triggered by viral infections.
Direct Oral Anticoagulants as Primary or Secondary Treatment for Heparin-Induced Thrombocytopenia (HIT) and Associated Thromboembolism (HITT)-A Meta-Analysis.
Heparin-induced thrombocytopenia (HIT) is associated with a high risk for thrombosis. The role of direct oral anticoagulants (DOACs) is still emerging and data are limited considering efficacy and safety among patients…
Outcomes From the Multicenter ACCRU-LY-1804/CARiBOU TRIAL (Cytarabine, Acalabrutinib and Rituximab Integrated With Bortezomib-Based Outpatient Therapy) in 1st Line Mantle Cell Lymphoma.
The CARiBOU trial, a phase 2 multicenter study, evaluated a multitargeted first-line treatment for mantle cell lymphoma (MCL) in 41 previously untreated patients.
Perioperative Factor VIII Replacement in Severe Hemophilia A During Neonatal Supracardiac Total Anomalous Pulmonary Venous Connection Repair.
A neonate with genetically confirmed severe hemophilia A underwent surgical repair of supracardiac total anomalous pulmonary venous connection.
Is There a Difference in Occurrence of Complications Between Adults With Hemoglobin SS and Hemoglobin SC Disease: An Extended Systematic Review.
This systematic review examined complications in adults with Hemoglobin SS (HbSS) and Hemoglobin SC (HbSC) disease, analyzing 31 studies.
Pampiniform venous plexus thrombosis in a 37 years-old male patient with severe thrombocytosis: a multifactorial aetiology.
A 37-year-old male presented with thrombosis of the pampiniform venous plexus, associated with severe thrombocytosis. The case revealed a multifactorial etiology, including potential genetic predispositions and acquired…
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