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1821 articles

September 202624

Clinical ResearchHematology

RENOIR phase 3 rituximab-lenalidomide vs rituximab as maintenance treatment in relapsed/refractory follicular lymphoma.

The RENOIR phase 3 trial evaluated rituximab plus lenalidomide (R2) versus rituximab alone (R) as maintenance therapy in older patients with relapsed/refractory follicular lymphoma.

Blood AdvSep 12, 2026Read summary
Clinical ResearchOncology (Medical)

A systematic review of international/national guidelines for the management of nasopharyngeal carcinoma: Convergence and divergence of recommendations.

This systematic review analyzed 26 clinical practice guidelines for nasopharyngeal carcinoma (NPC) published from January 2000 to November 2025.

CancerSep 12, 2026Read summary
Clinical ResearchOncology (Medical)

Neoadjuvant chemoimmunotherapy with afatinib for locally advanced head and neck squamous cell carcinoma (neoCHANCE-2): an open-label, single-arm, phase 2 study.

This phase 2, single-arm trial evaluated neoadjuvant chemoimmunotherapy with afatinib in 40 patients with locally advanced head and neck squamous cell carcinoma (LA-HNSCC).

J Immunother CancerSep 12, 2026Read summary
Clinical ResearchGeneral SurgeryOpen access

Robotic surgery for gastric gastrointestinal stromal tumors: a systematic review.

This systematic review evaluated robotic surgery for gastric gastrointestinal stromal tumors (GISTs) across 23 studies, including six comparative cohorts.

J Robot SurgSep 12, 2026Read summary
Clinical ResearchRadiology (Diagnostic)

OPEN: optimising patient experience in head and neck radiotherapy, a phase 3 randomised control trial comparing open versus closed face masks.

This phase 3 randomised trial compared three immobilisation approaches in non-claustrophobic patients receiving radical head and neck radiotherapy: a closed 5-point mask without surface-guided radiotherapy (SGRT), and…

Radiother OncolSep 12, 2026Read summary
Clinical ResearchUrology

Testosterone monitoring and supplementation in patients with intermediate- or high-risk prostate cancer treated with 6-36 months of androgen deprivation therapy and radiotherapy: a systematic literature review.

This systematic literature review examined testosterone monitoring, recovery, and replacement therapy in patients with intermediate- or high-risk localised prostate cancer treated with androgen deprivation therapy (ADT)…

Radiother OncolSep 12, 2026Read summary
Clinical ResearchOncology (Medical)

Tambotatug Pelitecan in Small-Cell Lung Cancer after Platinum-Based Therapy.

This phase 3, multicenter, open-label randomized trial compared tambotatug pelitecan with topotecan in patients whose small-cell lung cancer had progressed after first-line platinum-based therapy.

N Engl J MedSep 12, 2026Read summary
Clinical ResearchAnesthesiology

Effects of Esketamine on Postoperative Hospital Anxiety and Depression Scale Scores in Patients Undergoing Laparoscopic Radical Resection for Colorectal Cancer.

This randomized controlled trial examined the impact of intravenous esketamine on postoperative anxiety and depression in patients undergoing laparoscopic radical resection for colorectal cancer.

J Invest SurgSep 11, 2026Read summary
Case ReportEndocrinology

Clinically silent pheochromocytoma presenting as an adrenal incidentaloma: the importance of biochemical evaluation.

A woman in her late 70s presented with a 5 cm left adrenal mass found incidentally during imaging for unrelated issues. Despite well-controlled hypertension and no classic symptoms of catecholamine excess, biochemical…

BMJ Case RepSep 11, 2026Read case
Case ReportUrology

Vesicocutaneous fistula secondary to invasive bladder squamous cell carcinoma: an unusual initial presentation.

An elderly man presented with urinary leakage from an abdominal wound and signs of sepsis, following a progressive suprapubic swelling that ruptured.

BMJ Case RepSep 11, 2026Read case
Clinical ResearchOncology (Medical)

Cost-Effectiveness of Electronic Patient-Reported Outcome Measure Interventions in Cancer: Systematic Review and Parameter Extraction for Economic Modeling.

This systematic review evaluated the cost-effectiveness of electronic patient-reported outcome measures (ePROM) in cancer care, analyzing 34 publications from 27 studies.

J Med Internet ResSep 11, 2026Read summary
Case ReportMedical GeneticsOpen access

Reversible exacerbation of parkinsonism during epirubicin-cyclophosphamide chemotherapy in a patient with PTEN hamartoma tumor syndrome and young-onset Parkinson's disease.

A patient with a germline PTEN variant and young-onset Parkinson's disease developed severe exacerbations of parkinsonism during epirubicin-cyclophosphamide chemotherapy for bilateral breast cancer.

Neurol SciSep 11, 2026Read case
Clinical ResearchOncology (Medical)Open access

Natural products targeting the molecular pathology of salivary gland mucoepidermoid carcinoma: A systematic review of In vitro studies.

This systematic review evaluated the antitumor effects of natural products on human mucoepidermoid carcinoma cell lines. Fourteen in vitro studies were included, revealing that these interventions impaired cell…

Mol Biol RepSep 11, 2026Read summary
Case ReportOncology (Medical)

Primary Hepatic Lymphoma with Hepatocellular Carcinoma: A Case Report.

A patient with hepatocellular carcinoma (HCC) presented with atypical imaging findings that led to the discovery of primary hepatic lymphoma (PHL).

J Vis ExpSep 11, 2026Read case
Clinical ResearchOncology (Medical)

Effectiveness of Topical Huzhang Sanhuang with Standard Nursing for Chemotherapy-Induced Phlebitis: Randomized Controlled Study.

This randomized controlled trial assessed the effectiveness of topical Huzhang Sanhuang (HZSH) combined with standard nursing care in 94 hospitalized patients with chemotherapy-induced phlebitis (CIP).

J Vis ExpSep 11, 2026Read summary
Case ReportGeriatrics

Multidisciplinary management of an older adult with vascular Ehlers-Danlos syndrome and multiple autoimmune comorbidities.

An early 60s female with vascular Ehlers-Danlos syndrome (vEDS) presented with extensive comorbidities, including systemic lupus erythematosus and rheumatoid arthritis.

BMJ Case RepSep 11, 2026Read case
Case ReportOncology (Medical)Open access

Successful treatment of massive stage IIIB cervical cancer with a spindle cell component: A case report.

A 33-year-old woman presented with a massive cervical mass measuring 14 × 13 × 13 cm, accompanied by intermittent vaginal bleeding and progressive fatigue.

Medicine (Baltimore)Sep 11, 2026Read case
Case ReportHematologyOpen access

Pseudo-negative serum protein electrophoresis due to IgM aggregation in a patient with Waldenström macroglobulinemia: A case report.

A 79-year-old male presented with 10 months of anemia and bilateral lower limb and testicular edema. Following serological testing, serum protein electrophoresis, and genetic analysis, he was diagnosed with Waldenström…

Medicine (Baltimore)Sep 11, 2026Read case
Case ReportOncology (Medical)Open access

Successful treatment of a large-sized triple-negative breast cancer: A case report.

A 38-year-old female with stage IV triple-negative breast cancer (TNBC) experienced tumor recurrence and rapid progression one year post-surgery.

Medicine (Baltimore)Sep 11, 2026Read case
Case ReportOncology (Medical)Open access

Managing malignant recurrent pericardial effusion in a palliative patient with bleomycin sclerotherapy: A case report from Bangladesh.

A 50-year-old male with advanced lung cancer presented with recurrent malignant pericardial effusion, causing significant dyspnea and chest pain.

Medicine (Baltimore)Sep 11, 2026Read case
Clinical ResearchOncology (Medical)

DPYD c.85 T > C, DPYD c.496 A>G, and DPYD c.2194 G>A and severe toxicity to fluoropyrimidines in PREPARE and Alpe-DPD trials. An original study and meta-analysis.

This meta-analysis evaluated the impact of DPYD variants on severe toxicity from fluoropyrimidines in 17,485 patients across multiple studies, including the PREPARE and Alpe-DPD trials.

Pharmacol ResSep 11, 2026Read summary
Clinical ResearchOncology (Medical)

Patient-reported symptom monitoring in patients with lung cancer (SYMPRO-Lung trial): long-term, post-hoc survival results of a multicentre, stepped-wedged, cluster-randomised clinical trial.

The SYMPRO-Lung trial, a multicentre, stepped-wedged, cluster-randomised clinical trial, evaluated the impact of patient-reported outcome (PRO) symptom monitoring on survival in 446 patients with stage I-IV lung cancer.

Lancet OncolSep 11, 2026Read summary
Clinical ResearchOncology (Medical)

Economic advantage of daratumumab, bortezomib, lenalidomide, and dexamethasone vs bortezomib, lenalidomide, and dexamethasone for transplant-ineligible or transplant-deferred newly diagnosed multiple myeloma: A cost-per-responder evaluation.

This phase III comparative study evaluated the economic impact of daratumumab, bortezomib, lenalidomide, and dexamethasone (DVRd) versus bortezomib, lenalidomide, and dexamethasone (VRd) in transplant-ineligible or…

J Manag Care Spec PharmSep 11, 2026Read summary
Clinical ResearchOncology (Medical)

70-gene signature MammaPrint for early-stage HR-positive, HER2-negative breast cancer: Outcome in the MINDACT trial for key clinical-pathological high-risk subgroups.

The MINDACT trial explored the role of the 70-gene signature (MammaPrint) in patients over 50 with early-stage HR-positive, HER2-negative breast cancer.

Eur J CancerSep 11, 2026Read summary

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