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1998 articles

October 202624

Clinical ResearchOncology (Medical)Open access

A Phase I Dose-Escalation/Expansion Study of Fractionated-Dose and Multiple-Cycle Anti-PSMA-Targeted α-Emitter 225Ac-J591 in Patients with Prostate Cancer.

This phase I dose-escalation and expansion study evaluated fractionated and repeated-cycle 225Ac-J591 in patients with progressive metastatic prostate cancer resistant to androgen pathway modulation.

Clin Cancer ResOct 15, 2026Read summary
Case ReportOncology (Medical)

Recurrent Primary Angiosarcoma of the Breast: Challenges and Pitfalls in a Case Report.

A patient presented with a breast lesion and skin involvement; histopathology and immunohistochemistry confirmed low- to intermediate-grade primary breast angiosarcoma.

Ann Ital ChirOct 14, 2026Read case
Clinical ResearchObstetrics & Gynecology

The effect of three- and six-session prenatal haptonomy on pregnancy-related anxiety, distress, and psychological well-being: A randomized controlled trial.

This randomized controlled trial assigned 102 pregnant women to three-session prenatal haptonomy, six-session haptonomy, or routine antenatal care.

Afr J Reprod HealthOct 14, 2026Read summary
Clinical ResearchCardiology

Efficacy and Safety of Enlicitide in Hypercholesterolemia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

This systematic review and random-effects meta-analysis assessed efficacy and safety of oral enlicitide in adults with hypercholesterolemia.

Endocrinol Diabetes MetabOct 14, 2026Read summary
Clinical ResearchGastroenterology

Safety, Tolerability and Antiviral Activity of GST-HG131 in Chronic Hepatitis B: A Randomized, Double-Blind Phase IIa Study.

This randomized, double-blind, placebo-controlled Phase IIa trial assessed oral GST-HG131 in 45 adults with chronic hepatitis B receiving nucleos(t)ide analogue monotherapy.

Liver IntOct 14, 2026Read summary
Clinical ResearchDermatology

The Use of Cannabidiol in Cutaneous Wound Healing: A Systematic Review.

This qualitative systematic review assessed cannabidiol (CBD) for cutaneous wound healing, including in vivo studies and clinical trials identified through searches of seven databases. Six studies were included.

FASEB JOct 14, 2026Read summary
Clinical ResearchEndocrinology

Effects of glucagon-like peptide-1 (GLP-1) mono-agonists on reward processing in animal models: a systematic review.

This systematic review synthesised 66 preclinical studies of GLP-1 and GLP-1 receptor mono-agonists in animal models, examining food-, drug- and sexual-related reward.

Acta NeuropsychiatrOct 14, 2026Read summary
Case ReportPhysical Medicine & RehabilitationOpen access

Surgery to treat autonomic dysreflexia due to cubital tunnel syndrome in cervical spinal cord injury: a case report.

A 74-year-old woman with remote C6 spinal cord injury (AIS B) developed recurrent autonomic dysreflexia episodes that had not responded to standard measures.

Spinal Cord Ser CasesOct 14, 2026Read case
Clinical ResearchPsychiatry

Cortisol and cognition in psychotic disorders: A systematic review and multi-level meta-analysis.

This systematic review and three-level meta-analysis examined associations between cortisol and cognition in people with psychotic disorders.

Psychol MedOct 14, 2026Read summary
Case ReportCardiology

Case Report: Veno-Arteriovenous Extracorporeal Membrane Oxygenation for Management of Pheochromocytoma-Induced Cardiac Arrest in a Post-Partum Patient.

A 34-year-old woman, two days postpartum, was admitted to intensive care with hypertensive crisis and respiratory failure. CT showed an 18-cm left adrenal mass suspicious for pheochromocytoma.

A A PractOct 14, 2026Read case
Case ReportCardiothoracic Surgery

Robotic selective thoracic sympathectomy for hyperhidrosis: refined technique and anatomical variation.

Primary hyperhidrosis substantially impairs quality of life. Conventional sympathectomy risks compensatory hyperhidrosis through trunk disruption, whilst selective sympathectomy preserves the trunk while dividing…

Multimed Man Cardiothorac SurgOct 14, 2026Read case
Clinical ResearchOrthopedic Surgery

Antibiotic-Loaded Hydrogel, Calcium Bead, and Cement in Periprosthetic Joint Infection Following Hip-Knee Arthroplasty: A Systematic Review and Meta-Analysis of Commercially Available Products.

This systematic review and meta-analysis compared defensive antibacterial coating (DAC), calcium sulfate beads, and antibiotic-loaded bone cement for preventing or managing periprosthetic joint infection after total hip…

J Am Acad Orthop Surg Glob Res RevOct 14, 2026Read summary
Clinical ResearchPsychiatry

The psychological experience of body image change in adult stoma patients: A systematic review and qualitative meta-synthesis.

This systematic review and qualitative meta-ethnography synthesised English-language qualitative research on body image change in adults with a stoma. Eighteen studies involving 602 participants were included.

Br J Health PsycholOct 14, 2026Read summary
Clinical ResearchPhysical Medicine & RehabilitationOpen access

Clinical outcomes of low versus high intensity laser therapy in patients with subacute carpal tunnel syndrome: A randomized, single-blinded, controlled trial.

This single-blinded randomized controlled trial compared high-intensity laser therapy (HILT), low-level laser therapy (LLLT), and sham laser, each alongside physiotherapy, in 69 people with electromyography- and…

Lasers Med SciOct 14, 2026Read summary
Case ReportNeurosurgery

Painless Spontaneous Spinal Epidural Hematoma Mimicking Acute Ischemic Stroke: A Case Report.

A woman in her early 60s receiving anticoagulant and antiplatelet therapy developed neck tightness and numbness in both limbs without pain, followed by transient right hemiplegia and rapid neurological deterioration.

Ann Ital ChirOct 14, 2026Read case
Clinical ResearchNeurology

Preclinical and first-in-human evaluation of VG-3927/SAR448851, an oral small-molecule TREM2 agonist for Alzheimer's disease.

This study evaluated VG-3927, an oral, CNS-penetrant small-molecule TREM2 agonist, using preclinical models and a first-in-human randomized, double-blind, placebo-controlled phase 1 trial.

Sci Transl MedOct 14, 2026Read summary
Case ReportAnesthesiology

Preoperative Sedation via Cecostomy Tube in an Autistic Adolescent: A Case Report.

A 13-year-old autistic boy with a preexisting cecostomy tube for chronic constipation had previously been unable to tolerate oral or intramuscular preoperative sedation because of agitation and physical aggression.

A A PractOct 14, 2026Read case
Clinical ResearchGeneral Surgery

Modified LIFT via a Lateral Approach Versus Standard LIFT for Transsphincteric Anal Fistula: A Prospective Randomized Study.

This single-center prospective randomized study compared modified ligation of the intersphincteric fistula tract (LIFT) via a lateral approach with standard LIFT in adults with MRI-confirmed transsphincteric anal…

Ann Ital ChirOct 14, 2026Read summary
Clinical ResearchAnesthesiologyOpen access

Effect of a Subanesthetic Dose of Esketamine on Postoperative Sleep Disturbance After Oocyte Retrieval Under Intravenous Anesthesia: A Randomized Controlled Trial.

This randomized, double-blind, placebo-controlled trial assessed whether intravenous esketamine reduces postoperative sleep disturbance (PSD) in women undergoing oocyte retrieval with intravenous anesthesia.

Drug Des Devel TherOct 14, 2026Read summary
Case ReportNeurology

A 35-Year-Old Woman With Multiple Sclerosis and a New Atypical Thalamic Lesion: A Case Report From the National Multiple Sclerosis Society Case Conference Proceedings.

A 35-year-old woman with multiple sclerosis developed an enlarging thalamic lesion. Although new or enlarging lesions in MS can indicate disease activity, the lesion was ultimately diagnosed as a diffuse midline glioma…

Neurol Neuroimmunol NeuroinflammOct 14, 2026Read case
Clinical ResearchDermatologyOpen access

Targeting an IL-17/IL-36 pathogenic hub in hidradenitis suppurativa with a bispecific antibody.

This phase I/II proof-of-concept clinical trial evaluated HB0043, a bispecific antibody targeting IL-17A and IL-36R, in patients with severe, tunnel-dominant Hurley Stage III hidradenitis suppurativa.

Signal Transduct Target TherOct 14, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Camrelizumab plus chemotherapy as induction therapy followed by concurrent chemoradiotherapy and camrelizumab consolidation in limited-stage small cell lung cancer: a randomized phase II trial.

This randomized phase II trial compared a camrelizumab-based induction and consolidation strategy with induction chemotherapy followed by concurrent chemoradiotherapy (CRT) alone in previously untreated patients with…

Signal Transduct Target TherOct 14, 2026Read summary
Clinical ResearchAnesthesiology

Pericapsular Nerve Group Block Versus Femoral Nerve Block for Analgesia in Newly Admitted Patients With Hip Fractures: A Randomized Controlled Trial.

This randomized controlled trial compared preoperative pericapsular nerve group (PENG) block with femoral nerve block (FNB) in 60 newly admitted patients with hip fractures.

Clin J PainOct 14, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Volumetric discordance between ¹⁸F-FET-PET/MRI and MRI-based radiotherapy target volumes in high-grade glioma: a prospective pilot study (FETSMaRT).

This prospective pilot study enrolled 30 patients with WHO grade 3 or 4 high-grade glioma receiving postoperative radiotherapy.

J NeurooncolOct 14, 2026Read summary

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