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1064 articles

June 202624

Clinical ResearchOphthalmology

The Effects of a Digital Mindfulness Intervention on Mental Health and Vision-Related Quality of Life in Noninfectious Uveitis.

This single-center, single-masked, waitlist-controlled randomized clinical trial evaluated an 8-week digital mindfulness program in 100 adults with active or inactive noninfectious uveitis and at least mild baseline…

OphthalmologyJun 15, 2026Read summary
Clinical ResearchPsychiatry

The state urge to be physically active in anorexia nervosa: a systematic review of mechanisms and clinical implications.

This systematic review examined the State Urge to be Physically Active (SUPA) in individuals with anorexia nervosa (AN), analyzing 17 studies.

J Psychiatr ResJun 13, 2026Read summary
Clinical ResearchPsychiatry

A psychosocial manipulation of the error-related negativity does not transfer to the balance N1: A randomized controlled trial in anxious children.

This randomized controlled trial investigated the effects of a psychosocial intervention on the error-related negativity (ERN) and balance N1 in 54 anxious children aged 9-12 years.

J Affect DisordJun 12, 2026Read summary
Clinical ResearchPsychiatry

The effectiveness and tolerability of trauma-focused interventions for trauma symptoms in individuals who have psychosis: A systematic review and meta-analysis.

This systematic review and meta-analysis evaluated the effectiveness and tolerability of trauma-focused therapies (TFTs) for individuals with psychosis.

Schizophr ResJun 12, 2026Read summary
Clinical ResearchPsychiatryOpen access

Efficacy and Safety of Lumateperone and Other Atypical Antipsychotics Approved as Adjunctive Treatment for Major Depressive Disorder in the United States: A Network Meta-Analysis.

This network meta-analysis evaluated the efficacy and safety of lumateperone compared to other atypical antipsychotics in adults with major depressive disorder (MDD). The analysis included 10 randomized clinical trials.

Adv TherJun 12, 2026Read summary
Clinical ResearchPsychiatry

Factors associated with the percentage of individuals who initiate and discontinue naltrexone as a relapse prevention pharmacotherapy in opioid use disorder: A systematic review, meta-analysis and meta-regression.

This systematic review and meta-analysis examined initiation and discontinuation rates of naltrexone for relapse prevention in opioid use disorder (OUD) among 124,016 individuals.

AddictionJun 12, 2026Read summary
Clinical ResearchPsychiatry

A latent class analysis of clinical complexity: Secondary analysis of the collaboration leading to addiction treatment and recovery from other stresses (CLARO) randomized trial.

This secondary analysis of the CLARO randomized trial examined clinical complexity in 797 adults with opioid use disorder (OUD) and co-occurring depression and/or PTSD.

AddictionJun 12, 2026Read summary
Clinical ResearchPsychiatry

Wildfires and mental health in adults and youth: Meta-analysis of prevalence estimates by assessment timing, diagnostic criteria, and assessment methods.

This meta-analysis examined the prevalence of PTSD, depression, and anxiety in adults and youth exposed to wildfires, analyzing 33 studies.

J Trauma StressJun 12, 2026Read summary
Clinical ResearchPsychiatry

Randomised controlled trial of a web-based mental health, self-harm and suicide gatekeeper resource for parents and caregivers.

This two-arm randomised controlled trial evaluated a web-based mental health, self-harm and suicide gatekeeper resource for Australian parents and caregivers of children aged 5–17 years.

J Child Psychol PsychiatryJun 12, 2026Read summary
Clinical ResearchPsychiatry

A borderline personality disorder diagnosis may improve clinical psychology trainees' treatment beliefs.

This randomized 2 × 2 vignette experiment examined whether a borderline personality disorder (BPD) diagnosis and a character’s age influenced treatment beliefs and anticipated responses among 242 clinical psychology…

Br J Clin PsycholJun 12, 2026Read summary
Clinical ResearchObstetrics & Gynecology

Young bodies, aging ovaries: A systematic review and meta-synthesis of women's perspectives on spontaneous premature ovarian insufficiency.

This systematic review and meta-synthesis examined qualitative research on the experiences of women with spontaneous premature ovarian insufficiency (POI), excluding POI caused by medical interventions.

Int J Gynaecol ObstetJun 12, 2026Read summary
Clinical ResearchPsychiatry

Pilot randomized trial of intermittent theta-burst stimulation versus H-Coil transcranial magnetic stimulation for treatment-resistant depression.

This pilot randomized trial compared the effectiveness of intermittent theta-burst stimulation (iTBS) and H-Coil transcranial magnetic stimulation (rTMS) in 28 adults with treatment-resistant depression (TRD).

Psychiatry ResJun 11, 2026Read summary
Clinical ResearchPsychiatryOpen access

Employment and working conditions and risk of suicidal behaviors: a systematic review and meta-analysis of longitudinal studies.

This systematic review and meta-analysis examined the relationship between employment and working conditions and the risk of suicidal behaviors, focusing on longitudinal studies.

Scand J Work Environ HealthJun 11, 2026Read summary
Clinical ResearchOphthalmology

Examining neuroretinal alterations in autism spectrum disorder: a systematic review of OCT and OCT-A studies.

This systematic review examined neuroretinal alterations in individuals with Autism Spectrum Disorder (ASD) using Optical Coherence Tomography (OCT) and OCT Angiography (OCT-A).

Int J Psychiatry Clin PractJun 11, 2026Read summary
Clinical ResearchPsychiatry

Meta-analysis of brain and blood transcriptional signatures of neuroimmune dysregulation in Schizophrenia: convergent evidence for excessive complement system activity and CX3CL1-CX3CR1 axis disruption.

This meta-analysis examined transcriptional changes in neuro-immune regulators (NIREGs) in 532 individuals with schizophrenia compared to 623 healthy controls.

Brain Behav ImmunJun 11, 2026Read summary
Clinical ResearchPsychiatry

Risks Associated With Benzodiazepine Long-Term Use in Chronic Insomnia: A Systematic Review and (Network) Meta-Analysis.

This systematic review and meta-analysis evaluated the risks of long-term benzodiazepine use in adults with chronic insomnia, analyzing 27 studies.

J Sleep ResJun 11, 2026Read summary
Clinical ResearchPsychiatry

Critical reassessment of manic and psychotic episodes related to levetiracetam: a systematic review of published case reports.

Levetiracetam (LEV) is a widely used antiepileptic but associated with psychiatric side effects. While mild reactions are common, manic and psychotic episodes are less frequent, though clinically significant.

Int Clin PsychopharmacolJun 11, 2026Read summary
Clinical ResearchEndocrinology

Does heat affect the performance of bioceramic sealers? A systematic review of warm obturation.

This systematic review assessed how heat used in warm obturation affects bioceramic sealers in endodontic treatment. It identified 12 relevant studies examining bond strength, physicochemical properties, and clinical…

Minerva Dent Oral SciJun 11, 2026Read summary
Clinical ResearchPsychiatry

Cytokine changes during a 12-month pragmatic randomized trial in schizophrenia spectrum disorders comparing amisulpride, aripiprazole and olanzapine.

This pragmatic randomized controlled trial evaluated the immunomodulatory effects of amisulpride, aripiprazole, and olanzapine in 144 patients with schizophrenia-spectrum disorders.

Psychiatry ResJun 10, 2026Read summary
Clinical ResearchGeriatrics

Are psychotropic medications equivalent in fall risk among nursing home residents? A meta-analysis of pharmacologic subtypes and polypharmacy effects.

This meta-analysis examined the fall risk associated with various psychotropic medications in nursing home residents. It included 20 studies and found that typical antipsychotics (OR = 1.66) and atypical antipsychotics…

Int J Nurs StudJun 10, 2026Read summary
Clinical ResearchPsychiatry

Efficacy of lemborexant on sleep quality and neurocognitive outcomes among hospital rotating shift workers: A randomized, double-blind, placebo-controlled trial.

This randomized, double-blind, placebo-controlled trial evaluated the effects of lemborexant 5 mg on sleep quality and neurocognitive outcomes in rotating shift workers aged 20 to 60 years.

Sleep MedJun 10, 2026Read summary
Clinical ResearchNeurology

Reducing Recidivism After Traumatic Brain Injury: Results From the Re-entry Continuum for Brain Injury (RCBI) Trial.

The RCBI trial, a randomized controlled trial, evaluated an intervention for men with traumatic brain injury (TBI) nearing release from prison.

Arch Phys Med RehabilJun 10, 2026Read summary
Case ReportObstetrics & Gynecology

Journey from domestic violence to self-reliance: A case report from a tertiary care crisis center.

A 32-year-old married woman with two children experienced prolonged physical, emotional, and economic abuse by her husband, who had alcohol dependence.

Int J Gynaecol ObstetJun 10, 2026Read case
Clinical ResearchNeurology

Effects of light therapy on sleep and anxiety in Parkinson's disease: A pilot trial.

This randomized controlled trial investigated the effects of bright light therapy (BLT) and dim light therapy (DLT) on sleep and anxiety in 33 patients with Parkinson's disease.

J Affect DisordJun 9, 2026Read summary

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