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782 articles
October 202624
Immunogenicity and Safety of Co-administration of Adjuvanted Respiratory Syncytial Virus Prefusion F Protein Vaccine With 20-Valent Pneumococcal Conjugate Vaccine in Adults Aged ≥60 Years: A Randomized, Non-inferiority Trial.
This phase III, open-label, randomized non-inferiority trial compared concomitant versus one-month-apart administration of adjuvanted RSV prefusion F protein vaccine (RSVPreF3) and 20-valent pneumococcal conjugate…
Safety, Efficacy, and Immunogenicity of a Multivalent Adjuvanted Staphylococcus aureus Vaccine in Adults With Recent Skin and Soft Tissue Infections: An Observer-Blind, Randomized, Placebo-Controlled, Multinational Phase 1/2 Trial.
This observer-blind, randomized, placebo-controlled phase 1/2 trial evaluated a five-antigen Staphylococcus aureus vaccine with AS01E adjuvant in adults, including 194 participants aged 18–64 years with a recent S.
Efficacy of direct-acting antiviral regimens for acute HCV infection: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed interferon-free dual direct-acting antiviral regimens for acute or recently acquired HCV infection.
Hepatitis A-associated oxidative haemolysis in a patient with glucose-6-phosphate dehydrogenase deficiency with co-inherited sickle cell trait.
A young male presented with pruritus, nausea, and jaundice following travel to West Africa, lacking hepatitis A vaccination.
#aware.hiv Europe study: protocol for a stepped-wedge cluster randomised trial of a multimodal hospital-based implementation strategy targeting HIV indicator-condition-guided testing in European hospitals.
The #aware.hiv Europe study is a stepped-wedge cluster randomised trial conducted in 30 hospitals across ten European countries, aiming to improve HIV testing rates among patients with HIV indicator conditions.
A High-Energy Military Femoral Fracture With Multidrug-Resistant Infection: A Case Report.
A 37-year-old military man presented with a high-energy femoral fracture complicated by a multidrug-resistant infection. After multiple debridement procedures and the use of an external fixation device, he underwent…
Parenchymal Injury Caused by Complete Migration of a Bone of Japanese Horse Mackerel Within the Pancreatic Uncinate Process Through a Duodenal Diverticulum, Resulting in Sepsis and Multiple Pyogenic Liver Abscesses.
A 79-year-old man developed abdominal pain and fever three days after ingesting grilled Japanese horse mackerel. Imaging revealed a fish bone fully migrated into the pancreatic uncus through a duodenal diverticulum…
Iron or Multiple Micronutrient Powder Supplements With Malaria Chemoprevention in Rural Malawian Children: The IRMA Randomized Clinical Trial.
This randomized clinical trial evaluated the effects of iron supplements combined with malaria chemoprevention on cognitive outcomes in 6-month-old infants in rural Malawi.
Efficacy and safety of switching to once-daily oral doravirine plus raltegravir in virologically suppressed people with HIV-1: a randomized, open-label, multicentre phase 2 study (DORAL).
DORAL was a multicentre, open-label, randomized phase II trial in virologically suppressed adults with HIV-1 on stable antiretroviral therapy, without prior doravirine exposure or raltegravir resistance.
Effectiveness of Immersive and Embodied Enhancement via "Virtual Reality" on the Sustainability of Hand Hygiene Compliance:Protocol for a Randomized Controlled Trial of a School-Based Training Program.
This protocol describes a three-arm randomized controlled trial evaluating customized virtual reality (VR) handwashing education among secondary school students in Hong Kong.
Hernia, mesh, microbes, and phage promise: Mapping 35 years of evidence through a systematic review.
This systematic review examined published evidence on microbiology and outcomes of hernia mesh infections, including studies from 1990–2025. Of 584 studies meeting inclusion criteria, 32 contributed to meta-analysis.
Fulminant multi-organ failure associated with cereulide-producing Bacillus cereus after consumption of improperly stored rice.
A previously healthy male in his 20s presented with generalized seizures and severe hypoglycemia after eating improperly stored reheated rice.
Acute autoimmune hepatitis diagnosed concurrently with human immunodeficiency virus.
A woman in her 50s presented with jaundice and severe hepatocellular injury, later diagnosed with advanced HIV infection. Initial considerations included infectious hepatitis, but serology, imaging, and liver biopsy…
Temporal proximity to counseling is associated with longitudinal bedaquiline and antiretroviral therapy adherence in multidrug-resistant tuberculosis and HIV treatment.
This randomized controlled trial examined the relationship between counseling session timing and medication adherence in 76 participants receiving treatment for multidrug-resistant tuberculosis (MDR-TB) and HIV in South…
When Infection Mimics Vasculitis: Hydralazine-Induced ANCA-Associated Crescentic Glomerulonephritis in the Setting of Active Infective Endocarditis.
A 58-year-old man with a history of bicuspid aortic valve presented with fatigue, anemia, and acute kidney injury. He was diagnosed with subacute infective endocarditis after blood cultures grew Streptococcus mutans.
Geographical and temporal patterns of cutaneous leishmaniasis in Pakistan: insight from a decade of epidemiology.
This systematic review examined the geographical distribution and epidemiological trends of cutaneous leishmaniasis (CL) in Pakistan from 2014 to 2024.
Cardiac arrest revealing an occult interventricular septal hydatid cyst in a child.
An 11-year-old girl experienced sudden cardiac arrest during a biopsy of a dorsal hydatid cyst. After resuscitation, echocardiography revealed a 5.3 × 4.6 cm cyst in the interventricular septum, with CT showing liver…
A phase III randomized study: Immunogenicity and safety of a quadrivalent meningococcal conjugate vaccine in healthy adults, adolescents, and children in India and healthy adolescents and children in South Africa.
This Phase III randomized controlled trial assessed the immunogenicity and safety of a single dose of MenACYW-TT in healthy adults, adolescents, and children in India and in adolescents and children in South Africa.
Concordance of Microbiological and Histopathological Examination of Bone Biopsies in Diagnosing Diabetic Foot Osteomyelitis, a Systematic Review.
This systematic review evaluated the diagnostic concordance of histopathology and microbiology in bone biopsies from 308 adults with diabetic foot osteomyelitis (DFO).
Blackwater Fever Complicated by Severe Acute Kidney Injury and a Therapeutic Dilemma: A Case Report from Niger.
A 50-year-old woman with persistent Plasmodium falciparum infection and repeated antimalarial treatment, including artesunate, presented with fever, jaundice, and severe acute kidney injury (serum creatinine 1104.1…
Participant experiences of stopping ART as part of a clinical trial; findings from a qualitative study within the RIO trial in the United Kingdom.
This qualitative study explored the experiences of 20 cisgender men living with HIV who participated in the phase 2 RIO trial, which involved analytical treatment interruptions (ATIs).
Maternal and fetal outcomes of spinal tuberculosis in pregnancy: A systematic review and descriptive pooled analysis.
Spinal tuberculosis (TB) in pregnancy is rare and poses diagnostic, neurological, and obstetric challenges. Data are limited to isolated case reports and small series, precluding evidence-based guidance on management…
Comparison of Molecular Methods With Culture for Identifying Microbial Etiology in Pediatric Empyema Thoracis: A Systematic Review of Diagnostic Test Accuracy.
This systematic review evaluated the diagnostic accuracy of molecular methods versus culture for identifying microbial etiology in pediatric empyema thoracis.
Isolated Prostatic Tuberculosis Coexisting with Benign Prostatic Hyperplasia: A Case Report.
A 70-year-old man presented with one month of lower urinary tract symptoms and recurrent urinary retention requiring repeated catheterization.
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