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751 articles
September 202624
Sarcopenia in Indian adults with type 2 diabetes: a systematic review and meta-analysis of prevalence and associated factors.
This systematic review and meta-analysis assessed the prevalence of sarcopenia among Indian adults with type 2 diabetes mellitus (T2DM).
Retatrutide in adults with obesity and type 2 diabetes (TRIUMPH-2): a double-blind, parallel-group, randomised, placebo-controlled, phase 3 trial.
TRIUMPH-2 was a double-blind, parallel-group, randomised, placebo-controlled phase 3 trial at 92 centres in eight countries. It assessed once-weekly retatrutide in adults with obesity and type 2 diabetes.
GLP-1 receptor agonist exposure in the periconceptional period and adverse obstetric outcomes: A systematic review and meta-analysis.
This systematic review and random-effects meta-analysis examined observational studies comparing pregnancies with and without GLP-1 receptor agonist exposure during pregnancy or within six months before a positive…
Petrelintide, a human amylin analogue for the treatment of obesity (ZUPREME 1): a randomised, double-blind, placebo-controlled, phase 2 trial.
This multicentre, randomised, double-blind, placebo-controlled phase 2 trial assessed once-weekly petrelintide in adults with obesity or overweight with hypertension or dyslipidaemia, without type 2 diabetes.
Associations between prenatal bisphenol S with gestational age and preterm birth: A systematic review and meta-analysis.
This systematic review and meta-analysis examined whether prenatal bisphenol S (BPS) exposure is associated with gestational age or preterm birth.
Responder analysis of adaptive postural balance cardiac rehabilitation exercise in patients with coronary artery disease and type 2 diabetes: secondary analysis of a randomized trial.
This secondary analysis of a randomized trial evaluated the effects of adaptive postural balance cardiac rehabilitation exercise (APBCRE) versus aerobic exercise (AE) in 167 patients with coronary artery disease and…
Primary adrenal lymphoma presenting as primary adrenal insufficiency.
A man in his late 60s presented with symptoms of adrenal failure, including anaemia and hypercalcaemia. Initial tests indicated adrenal insufficiency, and imaging showed bilateral adrenal enlargement.
Non-thyroidal illness syndrome and isolated low triiodothyronine as prognostic markers in acute illness: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the relationship between thyroid hormone alterations and mortality in critically ill and cardiovascular patients.
Effects of concurrent training sequence on cardiometabolic risk factors in patients with type 2 diabetes: a systematic review and network meta-analysis.
This systematic review and network meta-analysis evaluated the effects of concurrent training sequences on cardiometabolic risk factors in patients with type 2 diabetes mellitus (T2DM).
Type A Insulin Resistance Syndrome Due to a Pathogenic Variant in the INSR Gene.
A woman in her 40s, initially diagnosed with type 1 diabetes, presented with a 30-year history of fluctuating insulin sensitivity and later developed insulin resistance, despite being non-obese.
Efficacy and safety of garetosmab, an activin A-blocking antibody, in fibrodysplasia ossificans progressiva (OPTIMA): a randomised, double-blind, placebo-controlled, phase 3 trial.
OPTIMA was a multicentre, randomised, double-blind, placebo-controlled phase 3 trial assessing monthly intravenous garetosmab in adults with fibrodysplasia ossificans progressiva.
Empagliflozin Promotes Natriuresis in Diabetic Patients with Cirrhotic Refractory Ascites: A Proof-of-Concept Study.
This randomized controlled trial investigated the effects of empagliflozin on natriuresis in 21 diabetic patients with decompensated cirrhosis and refractory ascites.
GLP-1 Receptor Agonists in Heart Failure: A Systematic Review and Meta-analysis with Phenotype-Specific Effects and Dual Analytical Frameworks.
This systematic review and random-effects meta-analysis assessed GLP-1 receptor agonists across heart-failure phenotypes and trial types, including 14 trials and 15,882 patients with heart failure.
Western versus Asian utilization of molecular testing for indeterminate thyroid nodules: A meta-analysis of divergent clinical impact.
This meta-analysis examined the use of molecular testing (MT) for indeterminate thyroid nodules in Western and Asian populations.
Blood pressure targets for hypertension in people with diabetes mellitus.
This Cochrane systematic review protocol aims to evaluate whether lower blood pressure targets (≤ 130/85 mmHg) reduce mortality and morbidity compared to standard targets (≤ 140 to 160/90 to 100 mmHg) in individuals…
Network meta-analysis of intrathyroidal injection of combined dexamethasone with lidocaine for subacute thyroiditis.
This meta-analysis evaluated the efficacy of intrathyroidal dexamethasone (Dex) versus oral prednisone and compared combination therapy of Dex with lidocaine to monotherapy in treating subacute thyroiditis (SAT).
A parathyroid adenoma masquerading as an oesophageal cyst.
A male in his 60s presented with ventricular fibrillation arrest, severe hypercalcaemia, and elevated parathyroid hormone levels, leading to a suspicion of primary hyperparathyroidism.
Palopegteriparatide for adults with chronic hypoparathyroidism: skeletal dynamics through 3 years of the phase 2 PaTH forward trial.
This randomized controlled trial evaluated the effects of palopegteriparatide in adults with chronic hypoparathyroidism over three years.
Primary Hyperparathyroidism Presenting as a Distal Femur Pathologic Fracture in an Adolescent: A Case Report.
A 17-year-old boy presented with a pathologic fracture of the distal femur, accompanied by bilateral distal femoral metadiaphyseal lytic lesions.
Efficacy and Safety of IGF-1 Receptor Inhibitors for Thyroid Eye Disease: Systematic Review and Meta-analysis of Randomized Controlled Trials.
This systematic review and meta-analysis pooled randomized controlled trials comparing IGF-1 receptor inhibitors with placebo for thyroid eye disease (TED).
The effect of lifestyle interventions in women with polyendocrine metabolic ovarian syndrome: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the effectiveness of lifestyle interventions in women with polyendocrine metabolic ovarian syndrome (PMOS).
Low Prevalence of Exploratory Biochemical Patterns Compatible with Osteomalacia in a Large Cohort of Participants with Low Serum 25-Hydroxyvitamin D Levels.
This study investigated the prevalence of biochemical patterns indicative of osteomalacia in a cohort with low serum 25-hydroxyvitamin D levels.
Housing Instability Associated With Cost-Related Nonadherence and Financial Toxicity in People With Uncontrolled Diabetes.
This randomized controlled trial examined the prevalence of housing instability among 600 adults with uncontrolled diabetes and its impact on cost-related nonadherence and financial toxicity.
suPAR Identifies Treatment-Resistant Inflammatory Risk Beyond hs-CRP in Type 2 Diabetes With Coronary Artery Disease: An Ancillary Analysis of BARI 2D.
This randomized controlled trial analyzed the role of soluble urokinase plasminogen activator receptor (suPAR) in patients with type 2 diabetes and coronary artery disease.
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