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1845 articles
May 202624
Long-term imaging characteristics of the pancreas related to diabetes induced by immune checkpoint inhibitor therapy.
A patient developed sudden hyperglycemia during pembrolizumab treatment for renal cell carcinoma, necessitating insulin therapy.
Image-guided interventional radiotherapy (modern brachytherapy) for treatment of vaginal intraepithelial neoplasia: single-institution experience and systematic literature review and meta-analysis.
This study evaluated the efficacy and safety of image-guided interventional radiotherapy (IG-IRT) for high-grade vaginal intraepithelial neoplasia (VaIN) through a retrospective case series of 10 patients and a…
Co-Occurrence of Achondroplasia and 16p11.2 Deletion Syndrome in a Child With Group 4 Medulloblastoma: Expanding the Spectrum of Dual Genetic Diagnoses.
A 13-year-old male with genetically confirmed achondroplasia (FGFR3 c.1138G > A) and a de novo 16p11.2 microdeletion developed metastatic Group 4 medulloblastoma at age 12, with leptomeningeal dissemination (M3).
Radiation Quality and Workflow in NRG GY017: Anti-PD-L1 (Atezolizumab) as an Immune Primer or Concurrently With Radiation Therapy for Node-Positive Locally Advanced Cervical Cancer.
This randomized controlled trial evaluated the quality of pretreatment radiation therapy (RT) plans in patients with node-positive locally advanced cervical cancer receiving atezolizumab.
Visualization of Scattered Tumor Regression Following Neoadjuvant Chemoimmunotherapy With a Novel Intraoperative PET/CT Scanner.
Neoadjuvant chemoimmunotherapy is being explored in locally advanced head and neck squamous cell carcinoma (HNSCC), yet the spatial patterns of pathologic response and clinical implications remain poorly characterized.
Outcomes of Response-Based Watch-and-Wait and Surgical Management After Total Neoadjuvant Therapy for Rectal Cancer: A Systematic Review and Meta-analysis.
This systematic review and meta-analysis evaluated the outcomes of response-based watch-and-wait (WW) versus surgical management (total mesorectal excision, TME) after total neoadjuvant therapy (TNT) for locally…
Comparison of PD-L1 expression between biopsy specimens and surgical resection specimens in non-small cell lung cancer: a meta-analysis.
This meta-analysis compared PD-L1 positivity in biopsy and surgical resection specimens from patients with non-small cell lung cancer, drawing on 13 studies involving 966 patients.
First-Line Pembrolizumab Plus Chemotherapy for Advanced Biliary Tract Cancer: China Subgroup Analysis of the Randomized Phase 3 KEYNOTE-966 Study.
This subgroup analysis of the randomized phase 3 KEYNOTE-966 study evaluated the efficacy of first-line pembrolizumab plus chemotherapy in 158 Chinese patients with advanced biliary tract cancer.
Multimodal Ultrasound Findings of Pediatric Inflammatory Myofibroblastic Tumor in the Liver: A Case Report.
An 8-year-old girl presented with persistent dizziness, leading to the discovery of a liver lesion. Initial imaging with CT and MRI suggested focal nodular hyperplasia.
Rare and complex three-way t(8;11;21) translocation in core-binding factor acute myeloid leukemia transforming into refractory mediastinal myeloid sarcoma: cytogenetic and molecular insights.
A young patient with core-binding factor acute myeloid leukemia (CBF-AML) and the RUNX1::RUNX1T1 fusion gene presented with a rare three-way t(8;11;21) translocation, alongside mutations in KIT, ASXL1, and TET2.
Paraneoplastic Immunoglobulin A Vasculitis With Rapidly Progressive Glomerulonephritis in a Patient With Metastatic Meningioma: Case Report and Literature Review.
A patient with metastatic meningioma presented with relapsing crescentic immunoglobulin A vasculitis with renal involvement, characterized by rapidly progressive glomerulonephritis.
Primary Pulmonary Epithelioid Inflammatory Myofibroblastic Sarcoma With SQSTM1::ALK Fusion.
A 58-year-old woman presented with cough and shortness of breath, leading to the discovery of a right lung mass. Transbronchial needle aspiration revealed spindle cells in a lymphoplasmacytic background, raising…
First-Line Systemic Treatments of Metastatic Hormone-Sensitive Prostate Cancer: Updated Systematic Review and Network Meta-Analysis.
This systematic review and network meta-analysis evaluated the efficacy and safety of first-line systemic combination therapies for metastatic hormone-sensitive prostate cancer (mHSPC) across 23 trials involving 18,689…
Polyostotic Fibrous Dysplasia Mimicking Widespread Skeletal Metastases on 68 Ga-PSMA PET/CT and Demonstrating a Superscan Pattern on Bone Scintigraphy.
A 63-year-old man with newly diagnosed prostate cancer underwent 68 Ga-PSMA PET/CT for staging, which revealed widespread skeletal uptake suggestive of metastatic disease. Bone scintigraphy showed a superscan pattern.
Autologous T-cell antigen coupler targeting HER2 (TAC01-HER2) in advanced or metastatic solid tumors.
This phase I clinical trial evaluated TAC01-HER2, an autologous T-cell product targeting HER2, in 23 patients with HER2-positive advanced solid tumors.
Primary isolated lumbar spine myeloid sarcoma: a rare case report and review of the literature.
A 39-year-old man presented with eight months of low back pain and radiculopathy, with normal neurological and laboratory findings.
NUT Midline Carcinoma of the Head and Neck: A Systematic Review and Pooled Survival Analysis.
NUT midline carcinoma (NMC) is an aggressive malignancy driven by NUTM1 fusions in poorly differentiated tumor cells. This pooled analysis evaluates the impact of primary tumor location on overall survival (OS) in head…
Distant metastasis in patients with cervical cancer: A systematic review and meta-analysis of incidence rates and common sites.
This systematic review and random-effects meta-analysis pooled observational studies of non-lymphatic distant organ metastases in patients with cervical cancer, excluding studies limited to patients presenting with…
Whole-brain radiotherapy with simultaneous integrated boost in treatment of patients with brain metastases: a systematic review and meta-analysis.
This systematic review and meta-analysis compared whole-brain radiotherapy with simultaneous integrated boost (WBRT-SIB) against WBRT alone for patients with brain metastases.
HER2-targeted PET/CT in breast cancer: a systematic review of lesion-level concordance with pathology.
This systematic review assessed the concordance of HER2-targeted PET/CT with pathology in breast cancer, analyzing 195 lesions from ten studies.
Outcomes in checkpoint inhibitor induced neuromuscular immune related adverse events: A case series.
Three patients with lung adenocarcinoma and gastroesophageal junction adenocarcinoma developed neuromuscular immune-related adverse events (ir-AEs) after treatment with pembrolizumab and nivolumab, respectively.
Inflammatory Myofibroblastic Tumour of Head and Neck: A Systematic Review Plus Meta-Analysis.
This systematic review and meta-analysis evaluated 22 studies involving 337 patients with inflammatory myofibroblastic tumors in the head and neck.
Evidence summary for the application and management of non-coring needles in implantable venous access devices for cancer patients.
This systematic review evaluated the use and management of non-coring needles in implantable venous access devices for cancer patients.
External Beam Radiation Therapy and Immunotherapy in the Management of Hepatobiliary Malignancies: A Meta-analysis of Treatment Response Rates.
This meta-analysis evaluated the efficacy of external beam radiation therapy (EBRT) combined with immunotherapy (IO) in patients with advanced hepatobiliary malignancies, specifically hepatocellular carcinoma (HCC) and…
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