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1566 articles
October 202624
Bone Accrual During Puberty Suppression and Gender-Affirming Therapy in Transgender Adolescents: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated bone mineral density (BMD) and z scores in transgender adolescents undergoing gonadotropin-releasing hormone agonist (GnRHa) therapy followed by gender-affirming…
Family-Centered Child Obesity Treatment: The TEAM UP Randomized Clinical Trial.
This pragmatic randomized clinical trial evaluated the effectiveness of enhanced standard of care with family-based behavioral treatment (ESOC+FBT) compared to enhanced standard of care alone (ESOC) in reducing percent…
Erythropoietin for Neonatal Hypoxic-Ischemic Encephalopathy: A Randomized Clinical Trial.
This multicenter randomized clinical trial evaluated the efficacy of erythropoietin (EPO) as an adjunct to therapeutic hypothermia in infants with moderate to severe hypoxic-ischemic encephalopathy (HIE).
Treatment of Multifood Allergy With Omalizumab or Multiallergen Oral Immunotherapy: A Randomized Clinical Trial.
This randomized clinical trial compared the efficacy of omalizumab versus multiallergen oral immunotherapy (MOIT) in treating multifood allergies in participants aged 1 to 55 years.
Platelet-rich plasma versus corticosteroid injections for facet and sacroiliac joint pain: a systematic review and meta-analysis with trial sequential analysis.
This systematic review and meta-analysis evaluated the efficacy of platelet-rich plasma (PRP) versus corticosteroid injections for treating facet and sacroiliac joint pain in 392 patients.
Hair Follicle-Derived Grafting for Chronic Cutaneous Wounds: A Systematic Review of Clinical Outcomes.
This systematic review evaluated the clinical outcomes of hair follicle-derived grafting techniques for chronic cutaneous wounds, analyzing 16 studies with 239 patients.
Quercetin in Myocardial Ischemia-Reperfusion Injury: Mechanistic Evidence, Cardioprotective Effects, and Translational Challenges.
This systematic review assessed the cardioprotective effects of quercetin in myocardial ischemia-reperfusion (I/R) injury, primarily in preclinical studies.
A Novel FAM111A Frameshift Variant Associated With Osteoclast Necroptosis and KCS2-like Syndrome.
Kenny-Caffey syndrome type II (KCS2) is a rare genetic disorder characterized by skeletal abnormalities, impaired growth, and developmental delay.
Efficacy of US-guided Hydrodissection for Carpal Tunnel Syndrome: A Prospective Randomized Controlled Trial.
This prospective randomized controlled trial evaluated the efficacy of three US-guided hydrodissection techniques for treating carpal tunnel syndrome (CTS) in adults with refractory symptoms.
Effects of Estriol-Lactobacilli Combination Versus Polycarbophil-Based Vaginal Moisturizer on Post-Radiation Vaginitis in Women With Cervical Cancer: A Randomized Controlled Trial.
This randomized controlled trial evaluated the efficacy of an estriol-lactobacilli combination vaginal tablet (E3/L) versus a polycarbophil-based vaginal moisturizer (PBVM) in 34 women with post-radiation vaginitis…
Topical Anesthetics Effectiveness in Management of Orthodontic Pain: A Systematic Review of Randomized Controlled Trials.
This systematic review evaluated the effectiveness of topical anesthetics in managing orthodontic pain, analyzing nine randomized controlled trials involving 456 participants aged 14-35.
Temporal Patterns of Outcomes After DMARD Tapering or Withdrawal in Rheumatoid Arthritis With Sustained Disease Control: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the effects of DMARD tapering and withdrawal in patients with rheumatoid arthritis (RA) who had sustained disease control.
Effectiveness of a Sodium Intake Monitoring Smartphone Application (NamakBan) on Clinical Outcomes of Patients Diagnosed With Hypertension: A Randomized Clinical Trial.
This randomized clinical trial evaluated the effectiveness of the NamakBan smartphone application for monitoring sodium intake in 88 adults with primary hypertension.
Efficacy and Safety of Traditional Chinese Medicine in Treating Chronic Obstructive Pulmonary Disease with Osteoporosis: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the efficacy and safety of traditional Chinese medicine (TCM) as an adjunct to conventional treatment for chronic obstructive pulmonary disease (COPD) with osteoporosis…
A systematic review and meta-analysis of preoperative MRI-based pelvimetry in predicting surgical difficulty in rectal cancer: Implications for personalised surgical planning.
This systematic review and meta-analysis evaluated the role of MRI-based pelvimetry in predicting surgical difficulty during total mesorectal excision (TME) for rectal cancer, involving 8,364 patients across 36 studies.
NIHSS and Large Artery Atherosclerosis Affect Efficacy of Dual Antiplatelet Therapy Versus Alteplase for Minor Stroke.
This randomized controlled trial analyzed the efficacy of dual antiplatelet therapy (DAPT) versus alteplase in patients with minor stroke (NIHSS 0-5) and assessed the impact of large artery atherosclerosis (LAA).
How I do it: meningioangiomatosis of the sylvian fissure. The need for a tailored functional neurosurgery.
A patient with drug-resistant epileptic seizures presented with meningioangiomatosis located in the right sylvian fissure, affecting the M1-M2 segments of the right middle cerebral artery.
Psychoeducation for Youth at Clinical High-Risk of Psychosis.
This clinical trial evaluated the effects of psychoeducation on 54 youth at clinical high risk of psychosis. After 2-6 months, significant improvements were noted in attenuated psychotic symptoms, depression, and…
Calcitonin-negative 'MTC-like' thyroid paraganglioma revealing an SDHD-related hereditary paraganglioma syndrome: functional confirmation of a non-canonical splice-site variant.
A 36-year-old woman presented with a 20-mm thyroid nodule classified as EU-TIRADS 4 and Bethesda III, with normal serum calcitonin levels.
DDX3Y loss-of-function variant in AZFa-like non-obstructive azoospermia highlights gaps in current Y-chromosome microdeletion testing.
A man with idiopathic non-obstructive azoospermia presented with an AZFa-like phenotype, characterized by elevated FSH and a normal karyotype.
Development and usability testing of a Spanish version of a mobile app-based adaptive coping skills intervention for critical illness survivors: Blueprint en español.
This multicenter clinical trial focused on adapting the Blueprint mobile app-based coping skills intervention for critical illness survivors to Spanish.
Anterior Stromal Melt Following Implantation of a Large Size Corneal Allogenic Intrastromal Ring Segment (CAIRS).
To report delayed anterior stromal melt following corneal allogenic intrastromal ring segment (CAIRS) implantation in a patient without known systemic or ocular risk factors.
Sutureless Epikeratophakia After Small Incision Lenticule Extraction: A Case Report to Correct Corneal Deformity.
An 18-year-old woman developed severe corneal thinning, with a residual stromal bed of 176 μm, and irregular hyperopic astigmatism in her left eye after a femtosecond laser malfunction during keratorefractive lenticule…
Chatbot Intervention and Cancer Risk Knowledge in Adolescents and Young Adults With Cancer Predisposition: A Randomized Clinical Trial.
This multicentre randomized clinical trial evaluated whether a tailored electronic chatbot improved cancer-risk understanding among English-speaking adolescents and young adults aged 12 to 24 years with one of nine…
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