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1821 articles
August 202624
Clavicular Osteoradionecrosis With 99mTc-FAPI-46 Uptake in a Patient With Breast Cancer.
A 65-year-old woman with a history of right breast cancer treated with mastectomy and chemoradiotherapy later developed cervical and supraclavicular metastatic disease and a left supraclavicular ulcer.
Assessing Graded Histological Regression as Basis for Treatment Modification after Neoadjuvant Therapy in LAGC: An Exploratory Phase II Study.
This prospective, single-centre, open-label, randomised phase II trial assessed whether graded histologic regression (GHR) below 50% could guide adjuvant chemotherapy modification in locally advanced gastric cancer…
Risk-stratified management of the clinically node-negative neck in early-stage oral squamous cell carcinoma: Elective neck dissection versus watch-and-wait with therapeutic dissection.
This systematic review evaluated the management of clinically node-negative (cN0) neck in early-stage oral squamous cell carcinoma (OSCC) by comparing elective neck dissection (END) to a watch-and-wait (W&W) approach…
Liquid Biopsy in Head and Neck Squamous Cell Carcinoma: A Systematic Review of the Scientific Literature.
This systematic review evaluates the role of liquid biopsy in head and neck squamous cell carcinoma (HNSCC), focusing on circulating tumor cells, ctDNA, and RNA biomarkers.
Primary Pulmonary Diffuse Large B-cell Lymphoma.
A 72-year-old man presented with two weeks of fever and mild upper respiratory symptoms. Initial CT and ¹⁸F-FDG PET/CT showed only nonspecific dependent ground-glass opacities (GGO).
Effects of five-element music therapy on chemotherapy patients with cancer: A systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis evaluated the effects of Five-Element Music Therapy (FEMT) on emotional state, sleep quality, and quality of life in 1588 cancer patients undergoing chemotherapy.
Trametinib-mediated MEK inhibition impairs cancer cell viability and invasion in patient-derived tumor avatars of glioblastoma with extraneural metastases: A proof-of-concept study.
A patient with glioblastoma (GBM) presented with rare extraneural metastases, characterized by aggressive molecular features including alterations in NF1, TP53, PTEN, and RB1.
Olaparib maintenance versus placebo or standard of care in ovarian cancer: a biomarker-driven systematic review and meta-analysis of randomized trials.
This systematic review and meta-analysis evaluated the efficacy and safety of olaparib maintenance therapy in advanced ovarian cancer patients who responded to platinum-based chemotherapy.
Multimodal Management of Advanced Metastatic Prostate Cancer: Excellent Response Following Resection of Brain Metastasis and 177Lu-PSMA Therapy.
A 68-year-old man with metastatic prostate adenocarcinoma underwent various treatments, including androgen-deprivation therapy and chemotherapy.
Molecular evaluation of residual disease following neoadjuvant chemotherapy in triple-negative breast cancer CALGB 40603 (Alliance).
This phase II randomized controlled trial evaluated residual disease (RD) in 340 pretreatment and 70 posttreatment samples from patients with triple-negative breast cancer (TNBC).
Modified endoscopic mucosal resection versus endoscopic submucosal dissection for rectal neuroendocrine tumors ≤10 mm: a systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis evaluated the efficacy of modified endoscopic mucosal resection (m-EMR) versus endoscopic submucosal dissection (ESD) for rectal neuroendocrine tumors (r-NETs) ≤10 mm, involving…
Early regression index-guided adaptive dose escalation in locally advanced rectal cancer: results of the prospective THUNDER-2 trial.
The THUNDER-2 trial evaluated the effectiveness of Early Regression Index (ERI)-guided adaptive dose escalation in patients with locally advanced rectal cancer (LARC) undergoing neoadjuvant chemoradiotherapy.
Pegtarazimod limits acute graft-versus-host disease mortality and severity in mice and is tolerated in patients.
This phase II clinical trial evaluated the efficacy and tolerability of pegtarazimod in patients with corticosteroid-refractory acute graft-versus-host disease (aGVHD).
Primary central nervous system T cell lymphoma involving multiple brain and spinal cord lesions with SETD2 mutation.
A 37-year-old Japanese man presented with impaired consciousness, and imaging revealed multiple contrast-enhancing lesions in the brain and spinal cord.
Longitudinal Molecular Characterization of a Rare TPM3::PDGFRB-Rearranged Myeloid/Lymphoid Neoplasm With Late CNL-Like Neutrophilic Evolution.
An elderly patient presented with hypereosinophilia and a balanced t(1;5)(q21;q33), with PDGFRB rearrangement detected in 70% of nuclei.
A Phase 1/2 study of ontorpacept (TTI-621) in combination with doxorubicin in patients with unresectable or metastatic high-grade leiomyosarcoma.
This multicentre Phase 1/2 clinical trial evaluated ontorpacept, a CD47–SIRPα pathway inhibitor, with doxorubicin in adults with advanced high-grade soft-tissue sarcoma; Phase 2 enrolled patients with high-grade…
Reconstruction of a Base of Fifth Metacarpal Tumor Using the Dubert Procedure: A Case Report.
A 63-year-old right-hand-dominant man was referred for reconstruction after intralesional resection of a myopericytic neoplasm at the base of the left fifth metacarpal.
Efficacy and tolerability of sodium-glucose cotransporter-2 inhibitors in transthyretin amyloid cardiomyopathy: A systematic review and stratified meta-analysis.
This systematic review and meta-analysis evaluated the efficacy and tolerability of sodium-glucose cotransporter-2 inhibitors (SGLT2i) in patients with transthyretin amyloid cardiomyopathy (ATTR-CM).
A systematic review and meta-analysis of radiation-induced oral complications in head and neck cancer: Prevalence and clinical outcomes.
This systematic review and meta-analysis evaluated the prevalence of radiation-induced oral complications, specifically xerostomia and oral mucositis, in head and neck cancer patients undergoing radiotherapy.
Clinical Heterogeneity and Long-Term Outcomes of Pediatric Gastrointestinal Stromal Tumors: A Series of Four Patients Highlighting SDH-Deficient and SDH-Intact Subtypes.
This report details four pediatric patients with gastrointestinal stromal tumors (GISTs) over 19 years. Two patients had SDH-deficient tumors, with one experiencing metastatic relapse.
Modulatory role of Blastocystis-derived solubilized antigens in colorectal carcinogenesis: A systematic review.
This systematic review examined the immunomodulatory effects of Blastocystis-derived solubilized antigens (BSA) on colorectal cancer (CRC) using six experimental studies.
Bispecific Antibodies Are Associated With Progressive Multifocal Leukoencephalopathy.
This report details five patients with relapsed and refractory multiple myeloma who developed progressive multifocal leukoencephalopathy (PML following treatment with bispecific antibodies.
Natural Killer Cell Immunotherapy After Allogeneic Hematopoietic Stem Cell Transplantation in Acute Leukemia Patients: Phase I Clinical Trial.
This Phase I clinical trial evaluated the safety and efficacy of interleukin-15-activated CD56+ cell infusion in patients with acute leukemia post-allogeneic hematopoietic stem cell transplantation.
Hyperpolarized [1-13C]-Pyruvate MRI Differentiates Benign Fibroma From High-grade Serous Carcinoma.
Two women with suspected ovarian cancer underwent preoperative imaging using hyperpolarized [1-13C]-pyruvate MRI and FDG PET/CT.
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