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1333 articles
September 202624
Iberdomide plus daratumumab and dexamethasone versus daratumumab, bortezomib, and dexamethasone in patients with relapsed or refractory multiple myeloma (EXCALIBER-RRMM): an open-label, randomised, controlled, phase 3 trial.
EXCALIBER-RRMM is an ongoing, open-label, randomised phase 3 trial comparing iberdomide, daratumumab, and dexamethasone with daratumumab, bortezomib, and dexamethasone in adults with relapsed or refractory multiple…
Sequential combination of anti-PD-1 antibody and PEG-IFNα in chronic hepatitis B patients: correlates of HBsAg loss with enhanced T-cell responses.
This pilot clinical trial investigated the sequential combination of anti-PD-1 antibody (sintilimab) and PEG-IFNα in ten virologically suppressed chronic hepatitis B patients.
Multimorbidity and the risk of depression: a systematic review of cohort studies.
This systematic review evaluated the longitudinal association between multimorbidity and the risk of developing depression, analyzing 17 cohort studies.
Effects of exercise interventions on gait, motor function, and balance in patients with Parkinson's disease: A meta-analysis with clinical implications.
This meta-analysis evaluated the effects of exercise interventions on gait, motor function, and balance in 714 patients with Parkinson's disease.
Bispectral index during remimazolam versus propofol sedation at matched depths: a randomized, double-blind crossover trial in healthy volunteers.
This randomized, double-blind crossover trial evaluated the bispectral index (BIS) during remimazolam versus propofol sedation in 16 healthy volunteers.
Losartan with add-on spironolactone for severe COVID-19 in the intensive care unit: a randomized controlled trial.
This randomized, open-label, parallel-group trial at five intensive care units in Marseille evaluated losartan, with conditional spironolactone, added to standard care for adults with severe COVID-19-related respiratory…
The Psychosocial Impact of Receiving Whole Genome and Whole Exome Sequencing Results in Adults: A Systematic Review.
This systematic review assessed the psychosocial impact of whole genome sequencing (WGS) and whole exome sequencing (WES) results in adults, analyzing 45 studies.
Network meta-analysis of intrathyroidal injection of combined dexamethasone with lidocaine for subacute thyroiditis.
This meta-analysis evaluated the efficacy of intrathyroidal dexamethasone (Dex) versus oral prednisone and compared combination therapy of Dex with lidocaine to monotherapy in treating subacute thyroiditis (SAT).
Efficacy and safety of oral minocycline hydrochloride 40 mg extended-release capsules (DFD-29) versus doxycycline in rosacea: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the efficacy and safety of oral minocycline hydrochloride 40 mg extended-release capsules (DFD-29) compared to doxycycline in treating rosacea.
Progression-free survival and objective response rate as a surrogate end point for overall survival in metastatic renal cell carcinoma: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the validity of progression-free survival (PFS) and objective response rate (ORR) as surrogate endpoints for overall survival (OS) in randomized controlled trials of…
Baricitinib vs. hydroxychloroquine for cutaneous lichen planus: an assessor-blind randomized controlled trial.
This randomized controlled trial compared the efficacy and safety of baricitinib and hydroxychloroquine in 32 patients with cutaneous lichen planus over 12 weeks.
Western versus Asian utilization of molecular testing for indeterminate thyroid nodules: A meta-analysis of divergent clinical impact.
This meta-analysis examined the use of molecular testing (MT) for indeterminate thyroid nodules in Western and Asian populations.
Comparative efficacy of various non-pharmacological therapies on cognitive function in patients with mild cognitive impairment or dementia: A network meta-analysis.
This network meta-analysis evaluated the efficacy of non-pharmacological therapies on cognitive function in 2082 patients with mild cognitive impairment or dementia.
A clinical study on the efficacy of a novel herbal medicine cocktail in enhancing HIFU treatment for adenomyosis: a pilot randomized controlled trial.
This pilot randomized controlled trial evaluated the efficacy of a Traditional Chinese Medicine (TCM) formula combined with High-Intensity Focused Ultrasound (HIFU) in 66 patients with adenomyosis.
The effect of alveolar recruitment maneuver on intraoperative hemodynamics: A randomized controlled trial.
This randomized controlled trial evaluated the impact of alveolar recruitment maneuver (RM) on intraoperative hemodynamics in 70 patients undergoing laparoscopic hysterectomy.
Systematic review and meta-analysis of biomarkers of sarcopenia and sarcopenic obesity.
This systematic review and meta-analysis examined the associations between biomarkers and sarcopenia/sarcopenic obesity (SO) in various populations.
Effectiveness and safety of ultrasound-guided quadratus lumborum block combined with low-dose spinal anesthesia versus general anesthesia in percutaneous nephrolithotomy: a randomized controlled trial.
This randomized controlled trial evaluated the effectiveness and safety of ultrasound-guided quadratus lumborum block (QLB) combined with low-dose spinal anesthesia (LDSA) versus general anesthesia (GA) in 70 adults…
The Role of Greenness in Heat-Related Mortality: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis examined the relationship between greenness and heat-related mortality across various countries.
Pancreatic arteriovenous malformations as a manifestation of hereditary haemorrhagic telangiectasia (Rendu-Osler-Weber disease): a systematic review.
This systematic review examined pancreatic arteriovenous malformations (AVMs) in patients with hereditary hemorrhagic telangiectasia (HHT), analyzing 19 cases from 13 studies.
Turning distress into distraction: using virtual reality during penicillin injections for rheumatic fever.
This phase IIA clinical trial evaluated the use of immersive virtual reality (VR) during subcutaneous penicillin injections in 10 participants aged 9-20 years with acute rheumatic fever.
Sarcopenia Is Associated With Severe Treatment Toxicity and Mortality in Older Adults With Advanced Cancer: A Secondary Analysis.
This secondary analysis of a randomized controlled trial examined the impact of sarcopenia on treatment outcomes in 161 older adults (≥ 70 years) with advanced cancer.
Intratumoral and Peritumoral Features for Predicting Microvascular Invasion in Hepatocellular Carcinoma: Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed the effectiveness of radiomics-based models in predicting microvascular invasion (MVI) in hepatocellular carcinoma (HCC).
Electronic patient-reported outcome platforms used in hematological cancers: a systematic review.
This systematic review examined electronic patient-reported outcome measures (ePROMs) in hematological cancers, identifying 14 platforms from 18 studies.
Comparison of bivalirudin versus heparin in percutaneous coronary intervention for patients with acute coronary syndrome: A meta-analysis.
This meta-analysis compared bivalirudin and heparin in patients with acute coronary syndrome undergoing percutaneous coronary intervention, including 11 RCTs and 17 cohort studies with 584,249 patients.
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