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1297 articles

September 202624

Clinical ResearchOrthopedic Surgery

Inducible displacement measured with radiostereometric analysis in primary knee arthroplasty: a systematic review of clinical studies.

This systematic review evaluated inducible displacement measured by radiostereometric analysis (RSA) in 23 studies of primary knee arthroplasty.

Acta OrthopSep 23, 2026Read summary
Clinical ResearchGeneral SurgeryOpen access

Efficacy and safety of Braun enteroenterostomy in patients undergoing pancreatoduodenectomy: a systematic review and meta-analysis.

This systematic review and meta-analysis evaluated the efficacy and safety of Braun enteroenterostomy (BEE) in 2731 patients undergoing pancreatoduodenectomy (PD).

Surg EndoscSep 23, 2026Read summary
Clinical ResearchOrthopedic Surgery

Intraoperative Calcar Fractures in Uncemented Total Hip Replacement: A Systematic Review.

This systematic review analyzed 60 studies involving 465,030 primary uncemented total hip arthroplasties (THAs) to evaluate intraoperative calcar fractures (IOCFs).

JBJS RevSep 23, 2026Read summary
Clinical ResearchOphthalmology

Preclinical and clinical evaluation of systemic danegaptide for the treatment of nonproliferative diabetic retinopathy.

This phase 1b clinical trial evaluated the safety and early efficacy of danegaptide, an oral medication, in patients with nonproliferative diabetic retinopathy (NPDR) and mild center-involved macular edema.

Sci Transl MedSep 23, 2026Read summary
Clinical ResearchEndocrinology

The effect of lifestyle interventions in women with polyendocrine metabolic ovarian syndrome: A systematic review and meta-analysis.

This systematic review and meta-analysis evaluated the effectiveness of lifestyle interventions in women with polyendocrine metabolic ovarian syndrome (PMOS).

PLoS MedSep 23, 2026Read summary
Clinical ResearchOncology (Medical)

Effect of Chinese medicine compound on intestinal bifidobacteria recovery and CD4+ T-Cell activation in postoperative chemotherapy patients with breast cancer .

This randomized controlled trial investigated the effects of a traditional Chinese medicine compound on intestinal bifidobacteria recovery and CD4+ T-cell activation in breast cancer patients undergoing postoperative…

Pak J Pharm SciSep 23, 2026Read summary
Clinical ResearchGastroenterologyOpen access

Is ultra-early endoscopy always beneficial? A systematic review and meta-analysis of timing-dependent outcomes in nonvariceal upper gastrointestinal bleeding.

This systematic review and meta-analysis evaluated the impact of ultra-early endoscopy (≤6 hours) versus early endoscopy (>6 hours) on clinical outcomes in adults with nonvariceal upper gastrointestinal bleeding…

PeerJSep 23, 2026Read summary
Clinical ResearchOncology (Medical)

Five-Year Follow-Up of the Phase III ASCOT Trial of Adjuvant S-1 After Resection for Biliary Tract Cancer.

This prespecified five-year follow-up of the multicenter, open-label, randomized phase III ASCOT trial assessed adjuvant S-1 versus observation after resection for biliary tract cancer in 440 patients in Japan.

J Clin OncolSep 23, 2026Read summary
Clinical ResearchAnesthesiologyOpen access

Effective Dose 90 of Programmed Intermittent Epidural Bolus Volume at Three Ropivacaine Concentrations with Dural Puncture Epidural for Labor Analgesia: A Randomized Sequential Allocation Study.

This randomized controlled trial evaluated the effective dose 90 (ED90) of programmed intermittent epidural bolus (PIEB) volume for labor analgesia using three concentrations of ropivacaine (0.075%, 0.1%, 0.125%) in 90…

Drug Des Devel TherSep 23, 2026Read summary
Clinical ResearchObstetrics & Gynecology

Intrauterine infusion of autologous platelet-rich plasma (PRP) versus granulocyte colony-stimulating factor (G-CSF) prior to single frozen blastocyst transfer in women with thin endometrium: a study protocol for a multicentre sequential multiple assignment randomised trial.

This multicentre randomized controlled trial aims to compare the effectiveness of intrauterine infusion of autologous platelet-rich plasma (PRP) versus granulocyte colony-stimulating factor (G-CSF) in women with thin…

BMJ OpenSep 23, 2026Read summary
Clinical ResearchRheumatology

Patient experiences with digital health interventions in self-management of rheumatic and musculoskeletal diseases: a systematic review and qualitative meta-synthesis.

This systematic review and qualitative meta-synthesis examined patient experiences with digital health interventions (DHIs) for self-management in rheumatic and musculoskeletal diseases (RMDs).

BMJ OpenSep 23, 2026Read summary
Clinical ResearchPediatrics

Pharmacokinetics and Dose Optimization of Ethambutol in Children on First-Line Antituberculosis Therapy: An Individual Patient Data Meta-Analysis.

This meta-analysis examined the pharmacokinetics of ethambutol (EMB) in 220 children aged 0.2-15 years undergoing first-line tuberculosis therapy.

J Infect DisSep 23, 2026Read summary
Clinical ResearchPsychiatry

QTc changes and early major adverse cardiovascular events associated with antidepressant treatment for major depressive disorder in adults: individual participant data network meta-regression of double blind randomised trials.

This network meta-analysis evaluated the impact of various antidepressants on QTc interval and early major adverse cardiovascular events (MACE) in adults with major depressive disorder.

BMJSep 23, 2026Read summary
Clinical ResearchEmergency MedicineOpen access

From dental adhesives to injectable hemostats: a scoping review of antimicrobial biomaterials for oral soft-tissue bleeding.

This scoping review examines antimicrobial biomaterials for managing oral soft-tissue bleeding, focusing on injectable materials that provide rapid hemostasis and antimicrobial protection.

BMC Oral HealthSep 23, 2026Read summary
Clinical ResearchPhysical Medicine & Rehabilitation

Telerehabilitation intervention after total knee arthroplasty in Iran: a feasibility and acceptability randomised controlled trial.

This randomized controlled feasibility trial evaluated a culturally adapted telerehabilitation program for Iranian patients post-total knee arthroplasty (TKA).

BMJ OpenSep 23, 2026Read summary
Clinical ResearchOncology (Medical)

Management of immune-related cutaneous adverse events associated with immune checkpoint inhibitors in patients with cancer: an evidence summary.

This systematic review synthesizes evidence on managing immune-related cutaneous adverse events (ircAEs) in cancer patients receiving immune checkpoint inhibitors (ICIs).

BMJ OpenSep 23, 2026Read summary
Clinical ResearchGeriatrics

Alzheimer's disease and related dementias in South and Southeast Asia: a systematic review and meta-analysis of epidemiology and associated factors.

This systematic review and meta-analysis examined the prevalence and associated factors of Alzheimer's disease and related dementias (AD/ADRDs) in South and Southeast Asia, analyzing data from 31 studies.

BMJ OpenSep 23, 2026Read summary
Clinical ResearchInfectious Diseases

Serotype-specific Immunity and Association With Pneumococcal Carriage Following 3+1, 3+0, and 2+1 Schedules of 10-valent Pneumococcal Conjugate Vaccine.

This phase II/III randomized controlled trial in Vietnam evaluated the relationship between serotype-specific memory B cells, IgG, and opsonophagocytic responses following different schedules of the 10-valent…

J Infect DisSep 23, 2026Read summary
Clinical ResearchOrthopedic Surgery

Total Hip and Knee Arthroplasty in the Pediatric and Adolescent Population: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis evaluated total hip arthroplasty (THA) and total knee arthroplasty (TKA) outcomes in patients under 25 years.

JBJS RevSep 23, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Acceptance and perceived efficacy of intraoral versus extraoral photobiomodulation for oral mucositis prevention in pediatric patients.

This randomized controlled trial evaluated the acceptance and perceived efficacy of intraoral (IO) versus extraoral (EO) photobiomodulation therapy for preventing oral mucositis in 32 pediatric oncology patients.

Support Care CancerSep 23, 2026Read summary
Clinical ResearchInfectious Diseases

In Host Mutational Adaptation of Mycobacterium Tuberculosis Complex Strains During Tuberculosis Infection.

This meta-analysis examined 5882 Mycobacterium tuberculosis complex (MTBC) genomes from 1044 patients to identify mutations associated with drug resistance during tuberculosis infection.

J Infect DisSep 23, 2026Read summary
Clinical ResearchInfectious Diseases

Effect of Delayed Antiretroviral Therapy Initiation on Anti-CD4 Autoantibodies in Antiretroviral Therapy-Naive People With HIV.

This randomized controlled trial investigated the effect of delayed antiretroviral therapy (ART) initiation on anti-CD4 autoantibodies in ART-naive individuals with HIV and CD4 > 500 cells/µL.

J Infect DisSep 23, 2026Read summary
Clinical ResearchGeneral SurgeryOpen access

Indocyanine green fluorescence angiography for prevention of anastomotic leak in colorectal surgery: a graded systematic review and meta-analysis with trial sequential analysis of randomized controlled trials.

This systematic review and meta-analysis evaluated the efficacy of indocyanine green fluorescence angiography (ICG-FA) in preventing anastomotic leaks (AL) in colorectal surgery, analyzing data from eight randomized…

Tech ColoproctolSep 23, 2026Read summary
Clinical ResearchEmergency Medicine

Efficacy of Inhaled Methoxyflurane for Acute Trauma Pain Management: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis assessed inhaled methoxyflurane versus control analgesics for acute trauma-related pain, synthesizing seven randomized controlled trials involving 1585 participants.

J Emerg MedSep 23, 2026Read summary

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