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406 articles
August 20266
Serum Copeptin Rises After Tolvaptan for Hyponatraemia, but Does Not Predict Risk of Rapid Sodium Rise: Pre-Specified Secondary Analysis of the TVFR Trial.
This study analyzed the effects of tolvaptan on serum copeptin levels in hospitalized patients with hyponatraemia, as part of a pre-specified secondary analysis of a randomized controlled trial.
Metabolic ketosis attenuates NLRP3 inflammasome activation and is associated with improvements in hepatic steatosis and liver stiffness in MASLD: a pilot randomized controlled trial.
This pilot randomized controlled trial investigated the effects of a C8-enriched medium-chain fatty acid formulation on metabolic and hepatic outcomes in 20 participants with metabolic dysfunction-associated steatotic…
Renal Resistive Index Responsiveness to a Mean Arterial Pressure Test As a Guide for Mean Arterial Pressure Target in the Early Phase of Septic Shock: A Physiological Study.
This randomized controlled trial examined the relationship between renal resistive index (RRI) responsiveness to mean arterial pressure (MAP) testing and renal outcomes in patients with early septic shock.
Targeting pain to improve opioid use disorder treatment outcomes: Results of a randomized trial.
This randomized trial tested whether adding telehealth psychosocial pain management to buprenorphine improved outcomes for 200 adults with opioid use disorder and pain lasting at least 3 months.
Frequent readmissions after hospitalization for alcohol withdrawal: a systematic review and meta-analysis.
This systematic review and meta-analysis examined readmission rates after inpatient detoxification for alcohol use disorder. Among 25 studies, the pooled readmission rate was 17% within 1 month and 44% within 1 year.
Micro(nano)plastics as dynamic vectors for hazardous agents: Bridging environmental transport to health impacts.
This systematic review examines the environmental transport and health impacts of micro(nano)plastics (MNPs), highlighting their role as vectors for hazardous agents.
July 202618
Safety and outcomes of dapagliflozin initiation in critically ill patients with acute kidney injury: A post-hoc analysis of the defender trial.
This post-hoc analysis of the DEFENDER trial evaluated the safety and outcomes of dapagliflozin in 212 critically ill patients with acute kidney injury (AKI).
Physical, mental and biochemical effects of probiotics in multiple sclerosis: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the effects of probiotic supplementation on physical, mental, and biochemical outcomes in adults with multiple sclerosis (MS).
Hypophosphataemia following iron infusion: a narrative review of an increasingly recognised complication.
This narrative review discusses five cases of hypophosphataemia following intravenous iron infusion, a complication increasingly recognized in clinical practice.
Nebivolol treatment improves hypertension-induced endothelial cell dysfunction by reducing TGF-β1-dependent senescence and normalizing mitochondrial indices.
This randomized controlled trial studied 71 patients with newly diagnosed hypertension to evaluate the effects of antihypertensive treatments on endothelial cell function.
Oral Semaglutide for Alcohol Use Disorder: A Randomized Clinical Trial.
This phase II randomized controlled trial assessed the effects of oral semaglutide on alcohol craving and consumption in 50 treatment-seeking adults with moderate to severe alcohol use disorder (AUD).
Efficacy of Sensory Stimulation in Intensive Care Unit Patients: A Systematic Review and Meta-analysis.
This systematic review and meta-analysis evaluated the effects of sensory stimulation (SS) on ICU patients, analyzing 22 randomized controlled trials with 1,522 participants.
Assessment and CommuniCation ExcelLEnce foR sAfe paTient outcomEs (ACCELERATE): A stepped-wedge cluster randomised trial evaluating the effectiveness of a nurse-led assessment and handover communication intervention on patient adverse events.
The ACCELERATE trial, a stepped-wedge cluster randomised trial conducted over 12 months in three metropolitan hospitals, evaluated a nurse-led assessment and communication intervention aimed at reducing patient adverse…
The impact of HIV coinfection on mpox patients: a systematic review and meta-analysis.
This systematic review and meta-analysis examined the impact of HIV coinfection on clinical outcomes in mpox patients, analyzing data from 29 studies involving 15,522 patients.
Time-Restricted Eating on Appetite and Inflammation in Adults With Obesity and Prediabetes: A Randomized Feeding Study.
This randomized controlled trial examined the effects of 10-hour time-restricted eating (TRE) versus a 16-hour usual eating pattern (UEP) on appetite and inflammation in 39 adults with obesity and prediabetes or…
Efficacy of CagriSema for Reaching Anthropometric Treatment Targets and Cardiometabolic Outcomes: A Secondary, Post hoc Analysis of REDEFINE 1.
This secondary analysis of the phase 3a REDEFINE 1 trial evaluated the efficacy of CagriSema in achieving anthropometric targets and cardiometabolic outcomes in adults with obesity.
Effect of fourth-line antihypertensive therapy on clinic systolic blood pressure in resistant hypertension: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the efficacy and safety of fourth-line antihypertensive therapies in reducing clinic systolic blood pressure (SBP) in 3,931 adults with resistant hypertension.
The safety and validity of remote ischemic preconditioning training on sleep disorder after stroke: a randomized controlled trial.
This randomized controlled trial investigated the effects of remote ischemic preconditioning (RIPC) on sleep quality, quality of life, and anxiety in 86 post-stroke insomnia patients.
Development of a core descriptor set for studies assessing interventions for diabetes-related foot ulceration.
This systematic review developed a core descriptor set (CDS) for studies on diabetes-related foot ulceration, addressing the inconsistency in reporting participant characteristics.
Specialized pro-resolving mediators in obesity and overweight conditions: A systematic review of human and animal evidence on comparative differences and associations.
This systematic review examined the role of specialized pro-resolving mediators (SPMs) in obesity and overweight conditions, analyzing 27 studies across human and animal populations.
Asymptomatic spinal cord lesions in Multiple Sclerosis: A systematic review and meta-analysis of subclinical disease activity.
This systematic review and meta-analysis examined the occurrence of new asymptomatic spinal cord lesions (aSCLe) in clinically stable patients with Multiple Sclerosis (MS).
Acute Kidney Injury After Intensive Blood Pressure Lowering Following Successful Endovascular Thrombectomy.
This randomized controlled trial analyzed the impact of intensive blood pressure management on acute kidney injury (AKI) in 287 patients with acute ischemic stroke post-endovascular thrombectomy.
In Vitro comparison of herbal and conventional antifungals against Candida strains in Oral candidiasis: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the in vitro antifungal activity of herbal versus conventional antifungals against various Candida strains.
Alternating bundle branch block: What is the mechanism?
A 60-year-old gentleman with severe left ventricular systolic dysfunction, multivessel coronary artery disease, and chronic kidney disease presented with New York Heart Association (NYHA) class III breathlessness…
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